Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

familial generalized lentiginosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

familial generalized lentiginosis

MONDO:0007891

Also known as:familial lentigines profusafamilial multiple lentigines syndrome without systemic involvementlentiginosis profusa

Overview

Familial generalized lentiginosis is a rare, inherited, skin hyperpigmentation disorder characterized by widespread lentigines without associated noncutaneous abnormalities. Patients present multiple brown to dark brown, non-elevated macula of 0.2 to 1 cm in diameter, spread over the entire body, sometimes including palms or soles, but never oral mucosa.

GeneticsAutosomal dominant

Clinical Presentation

Features include: Hypermelanotic macule.

Explore clinical features

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for familial generalized lentiginosis.

10 publications have been identified in PubMed for familial generalized lentiginosis. Research spans Review / Meta-Analysis (40%), Case Report / Case Series (30%), and Epidemiology / Natural History (30%).

Research Type	Count	% of Total
Research summaries	4	40%

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 4:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:151001

Orphanet

European rare disease database

Orphanet:231040

GARD

Genetic and Rare Diseases Info Center

GARD:17158

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

familial generalized lentiginosis

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications