Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome

MONDO:0016213

Overview

Leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome is a rare, syndromic nail anomaly disorder characterized by the association of leukonychia totalis with acanthosis-nigricans-like lesions (occurring in the neck, axillae and abdomen regions) and hair dysplasia, manifesting with dry, brittle hair which presents an irregular pattern of complete or incomplete twists and an irregular surface with londitudinal furrows on electronic microscopy.

ResearchLimited published research (3 articles)

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome.

3 publications have been identified in PubMed for leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome. Research spans Case Report / Case Series (67%) and Epidemiology / Natural History (33%).

Recent Publications

Temiz SA (2026). [PMID: 41742816](https://pubmed.ncbi.nlm.nih.gov/41742816/). *Journal of clinical research in pediatric endocrinology*. [Epidemiology / Natural History]
Alkorashy M (2025). [PMID: 41300744](https://pubmed.ncbi.nlm.nih.gov/41300744/). *Genes*. [Case Report / Case Series]
Nguyen C (2024). [PMID: 38994911](https://pubmed.ncbi.nlm.nih.gov/38994911/). *Pediatric dermatology*. [Case Report / Case Series]

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:36 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:210133

GARD

Genetic and Rare Diseases Info Center

GARD:20448

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome

Overview

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team