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exfoliation syndrome (XFG) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

exfoliation syndrome

MONDO:0008327

Also known as:XFGXFSpseudoexfoliation glaucoma

Find Clinical TrialsTrials

Overview

An autosomal dominant disorder caused by mutations in the LOXL1 gene, encoding lysyl oxidase homolog 1. The condition is characterized by abnormal fibrillar extracellular material in anterior segment tissues, and may lead to glaucoma.

Clinical Trials20 registered · 11 recruiting

Diagnosis

Biomarker and diagnostic research for exfoliation syndrome has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

20 clinical trials registered, 11 recruiting. Interventions under study include medical devices, procedural interventions, other interventions, and drug therapy. Pipeline includes 1 PHASE4, 1 PHASE1, 11 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06523751](https://clinicaltrials.gov/study/NCT06523751)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:55 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:529819

Questions for Your Care Team

→Are any of the 20 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Laboratory research	23	26%
Disease patterns and progression	17	20%
Research summaries	16	18%
Testing and diagnosis research	12	14%
Clinical study results	11	13%
Patient case studies	4	5%
Other research	2	2%
New treatment approaches	2	2%

exfoliation syndrome

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications