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Extranodal nasal NK/T cell lymphoma (NKTCL) is defined in the packet as a rare, malignant neoplasm mainly affecting men in the fifth decade of life. It usually arises in the nose, paranasal sinuses, orbits or upper airway. A few cases presenting primarily in the lymph nodes have also been described. Synonyms recorded include extranodal NK/T-cell lymphoma, nasal type, angiocentric T-cell lymphoma, and lethal midline granuloma. The packet supplies no certified prevalence estimate.
The packet lists no known genes and no inheritance pattern for this condition, so the causes are not described in this packet. This reflects what was supplied and is not a statement that no causes are known.
The packet supplies no diagnostic methods or criteria for this condition, and no newborn screening information.
The packet records no approved treatments and no foundational therapies for this condition. Orphan-drug records are present, but most list indications for a different lymphoma; the two records with indications for extranodal NK/T-cell lymphoma carry the statuses DESIGNATED and WITHDRAWN. Orphan designation is not FDA approval, so no FDA-approved option is certified in this packet.
29 trials found
Prognosis is not certified in this packet beyond the definition's statement that advanced disease stages are associated with a poor prognosis.
The packet lists clinical-trial records for the search term used. Records specific to NK/T-cell lymphoma include NCT03728972, a Phase 2 study in early-stage NK/T-cell lymphoma, nasal type (Memorial Sloan Kettering Cancer Center; active, not recruiting; start 2018-11-09, listed completion 2026-11-01); NCT04414163, a Phase 2 study in relapsed or refractory extranodal NK/T cell lymphoma, nasal type (ImmuneOncia Therapeutics; active, not recruiting; 2020-10-27 to 2027-02-28); and NCT07502768, a Phase 1 study in relapsed or refractory NK/T-cell lymphoma (sponsor Rong Tao; recruiting; 2026-04-30 to 2028-12-30). Other listed records address hematologic or other cancers more broadly. Trial titles are not claims about the effect of any intervention.
Data assembled from 5 of 12 sources · Last updated Nov 3, 2026, 4:43 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning extranodal nasal NK/T cell lymphoma
Updated Jul 21, 2026
A single-center study in Vietnam evaluates real-world outcomes of frontline multimodal treatment strategies for localized extranodal NK/T-cell lymphoma, nasal type. The findings contribute to understanding treatment efficacy in this rare lymphoma subtype.
A case report highlights the occurrence of synchronous rectal cancer and extranodal NK/T-cell lymphoma, nasal type. This unique presentation may provide insights into the interplay between these two malignancies.
New research identifies DNA methylation signatures that differentiate extranodal NK/T-cell lymphoma from EBV-positive nodal T/NK-cell lymphoma. This discovery may help in identifying prognostic subgroups, enhancing patient stratification and treatment approaches.