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Familial osteodysplasia, Anderson type is a rare, genetic dysostosis disorder characterized by craniofacial bone abnormalities (i.e. midface hypoplasia, broad, flat nasal bridge, narrow, thin prognathic mandible with pointed chin, malocclusion, partial dental agenesis) associated with additional osseous anomalies, including scoliosis, calvarial thinning, pointed spinous processes, clinodactyly and abnormal phalanges. Elevated erythrocyte sedimentation rate, hyperuricemia and hypertension have also been reported. There have been no further descriptions in the literature since 1982.
Features include very common findings: Malar flattening, Mandibular prognathia, Pointed chin, and Abnormal midface morphology and others; and common findings: Carious teeth, Abnormal rib morphology, Missing ribs, and Abnormal form of the vertebral bodies and others. 31 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Bones and joints | 9 | Sideways curvature of the spine (scoliosis), Increased susceptibility to fractures, Recurrent fractures |
Phenotype severity distribution: 24 very common features, 5 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 4:50 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Brain and nerves | 2 | Depressed nasal ridge, Seizure |
Head and neck | 1 | Mandibular prognathia |
Heart and blood vessels | 1 | Hypertension |
Arms and legs | 1 | Clinodactyly of the 5th finger |