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familial sick sinus syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

familial sick sinus syndrome

MONDO:0012061

Also known as:familial sinus node dysfunctionhereditary sick sinus syndromeSSS1

Overview

Sick sinus syndrome is a rare cardiac rhythm disease, usually of the elderly, characterized by electrocardiographic findings of sinus bradycardia, atrial fibrillation, atrial tachycardia sinus arrest, or sino-atrial block, and that manifest with symptoms like syncope, dizziness, palpitations, fatigue, or even heart failure. It results from malfunction of the cardiac conduction system, probably secondary to degenerative fibrosis of nodal tissue in the elderly or secondary to cardiac disorders in younger patients.

OnsetADULT

Diagnosis

Biomarker and diagnostic research for familial sick sinus syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for familial sick sinus syndrome.

33 publications have been identified in PubMed for familial sick sinus syndrome. Research spans Case Report / Case Series (30%), Basic Science / Preclinical (24%), and Epidemiology / Natural History (21%).

Research Type	Count	% of Total
Patient case studies	10	30%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 5:33 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:166282

GARD

Genetic and Rare Diseases Info Center

GARD:13663

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

familial sick sinus syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

SCN5A (c.4720G> A): a rare genetic variant associated with familial sick sinus syndrome and sudden cardiac death.

familial sick sinus syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

SCN5A (c.4720G> A): a rare genetic variant associated with familial sick sinus syndrome and sudden cardiac death.