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A temporal lobe epilepsy characterized by autosomal dominant inheritance of complex or partial seizures and childhood febrile seizures that has material basis in variation in the chromosome region 12q22-q23.3.
Features include common findings: Febrile status epilepticus. 5 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Brain and nerves | 5 | Bilateral tonic-clonic seizure, Febrile seizure (within the age range of 3 months to 6 years), Focal impaired awareness seizure |
Phenotype severity distribution: 1 common feature.
No clinical trials have been registered for familial temporal lobe epilepsy 2.
2 publications have been identified in PubMed for familial temporal lobe epilepsy 2. Research spans Review / Meta-Analysis (50%) and Case Report / Case Series (50%).
Alrabadi B (2026). [PMID: 42258029](https://pubmed.ncbi.nlm.nih.gov/42258029/). *Epileptic Disord*. [Review / Meta-Analysis]
Wang C (2025). [PMID: 41177904](https://pubmed.ncbi.nlm.nih.gov/41177904/). *Acta epileptologica*. [Case Report / Case Series]
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 1:00 AM UTC
Online Mendelian Inheritance in Man
AI-curated news mentioning familial temporal lobe epilepsy 2
Updated Aug 28, 2026
A recent exome sequencing study identifies rare genetic variations in adults with surgically treated temporal lobe epilepsy. This research could enhance understanding of the genetic underpinnings of this condition and inform future therapeutic strategies.
A recent study published in PubMed highlights alterations in the glymphatic system and brain morphology in patients with temporal lobe epilepsy. These findings may provide insights into the underlying mechanisms of the disease and potential therapeutic targets.