Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Feingold syndrome type 2 (FS2) is a rare inherited malformation syndrome characterized by skeletal abnormalities and mild intellectual disabilities similar to those seen in Feingold syndrome type 1 (FS1) but that lacks the manifestations of gastrointestinal atresia and short palpebral fissures.
Features include very common findings: Intellectual disability; and common findings: Intestinal atresia, Short middle phalanx of the 5th finger, Secondary microcephaly, and Short middle phalanx of the 2nd finger and others. 11 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Arms and legs | 4 | Short middle phalanx of the 5th finger, Short middle phalanx of the 2nd finger, 2-3 toe syndactyly |
Biomarker and diagnostic research for Feingold syndrome type 2 has been reported in the published literature.
Phenotype severity distribution: 1 very common feature, 7 common features.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for Feingold syndrome type 2.
46 publications have been identified in PubMed for Feingold syndrome type 2. Research spans Basic Science / Preclinical (37%), Clinical Trial Publication (17%), and Case Report / Case Series (15%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 17 | 37% |
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about Feingold syndrome type 2
Growth and development | 2 | Short stature, Postnatal growth retardation |
Heart and blood vessels | 1 | Ventricular septal defect |
Digestive system | 1 | Intestinal atresia |
Head and neck | 1 | Secondary microcephaly |
Brain and nerves | 1 | Intellectual disability |
8 |
17% |
Patient case studies | 7 | 15% |
Disease patterns and progression | 6 | 13% |
Research summaries | 5 | 11% |
New treatment approaches | 2 | 4% |
Testing and diagnosis research | 1 | 2% |
Davies I (2026). [PMID: 41287212](https://pubmed.ncbi.nlm.nih.gov/41287212/). *Diabetes Obes Metab*. [Basic Science / Preclinical]
Šáhó R (2026). [PMID: 41928800](https://pubmed.ncbi.nlm.nih.gov/41928800/). *Res Sq*. [Epidemiology / Natural History]
Retuerto-Guerrero M (2026). [PMID: 41400930](https://pubmed.ncbi.nlm.nih.gov/41400930/). *Rheumatology (Oxford, England)*. [Clinical Trial Publication]
Zhao X (2026). [PMID: 41916009](https://pubmed.ncbi.nlm.nih.gov/41916009/). *Biochem Biophys Res Commun*. [Basic Science / Preclinical]
Li D (2026). [PMID: 41865505](https://pubmed.ncbi.nlm.nih.gov/41865505/). *Mol Genet Metab*. [Clinical Trial Publication]
Sacchetto L (2026). [PMID: 41403717](https://pubmed.ncbi.nlm.nih.gov/41403717/). *Lancet regional health. Americas*. [Clinical Trial Publication]
Tzeravini E (2026). [PMID: 41575482](https://pubmed.ncbi.nlm.nih.gov/41575482/). *Current obesity reports*. [Review / Meta-Analysis]
Weijers JAM (2026). [PMID: 42066686](https://pubmed.ncbi.nlm.nih.gov/42066686/). *ESMO Open*. [Basic Science / Preclinical]
Wu P (2026). [PMID: 41719615](https://pubmed.ncbi.nlm.nih.gov/41719615/). *Biochemical and biophysical research communications*. [Basic Science / Preclinical]
Samara AA (2026). [PMID: 41595474](https://pubmed.ncbi.nlm.nih.gov/41595474/). *Genes*. [Case Report / Case Series]