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fetal valproate syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

fetal valproate syndrome

MONDO:0012275

Also known as:fetal valproic acid syndromefoetal valproic acid syndromeFVS

Overview

Fetal valproate syndrome (FVS), is an anticonvulsant drug-related embryofetopathy that can occur when a fetus is exposed to valproic acid (VPA), characterized by distinct facial dysmorphism, congenital anomalies and developmental delay (especially in language and communication).

ResearchLimited published research (8 articles)

Diagnosis

Biomarker and diagnostic research for fetal valproate syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for fetal valproate syndrome.

8 publications have been identified in PubMed for fetal valproate syndrome. Research spans Review / Meta-Analysis (38%), Case Report / Case Series (25%), and Epidemiology / Natural History (25%).

Recent Publications

Pack AM (2026). [PMID: 40083742](https://pubmed.ncbi.nlm.nih.gov/40083742/). *Epilepsy Curr*. [Epidemiology / Natural History]
Vigod SN (2025). [PMID: 39936923](https://pubmed.ncbi.nlm.nih.gov/39936923/). *Can J Psychiatry*. [Review / Meta-Analysis]
Singanamalla B (2025). [PMID: 39171837](https://pubmed.ncbi.nlm.nih.gov/39171837/). *QJM*. [Case Report / Case Series]
Angus-Leppan H (2024). [PMID: 38896265](https://pubmed.ncbi.nlm.nih.gov/38896265/). *J Neurol*. [Review / Meta-Analysis]
Sinha N (2024). [PMID: 39055475](https://pubmed.ncbi.nlm.nih.gov/39055475/). *Cureus*. [Case Report / Case Series]
Pack AM (2024). [PMID: 38748979](https://pubmed.ncbi.nlm.nih.gov/38748979/). *Neurology*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 8:47 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:609442

Orphanet

European rare disease database

Orphanet:1906

GARD

Genetic and Rare Diseases Info Center

GARD:5447

Questions for Your Care Team

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fetal valproate syndrome

Overview

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team