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florid cemento-osseous dysplasia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

florid cemento-osseous dysplasia

MONDO:0019368

Also known as:florid osseous dysplasiafocal cemento-osseous dysplasiaGigantiform cementoma

Overview

Florid cemento-osseous dysplasia (FCOD) is a rare fibro-osseous lesion in the jaw that predominantly affects middle-aged women of African descent. It is generally asymptomatic or may manifest with pain and gingival swelling. Radiologically, it is characterized by multiple dense lobulated bone lesions, often symmetrically located in various regions of the jaw.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Abnormal mandible morphology, Abnormal maxilla morphology, Abnormal bone structure (abnormal bone structure), and Abnormal trabecular bone morphology and others; and common findings: Abnormal midface morphology, Periapical bone loss, Multiple impacted teeth, and Hyperplasia of the maxilla. 23 total HPO annotations.

Organ System	Phenotype Count	Example Features
Bones and joints	5

Diagnosis

Biomarker and diagnostic research for florid cemento-osseous dysplasia has been reported in the published literature.

Prognosis

Phenotype severity distribution: 5 very common features, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for florid cemento-osseous dysplasia.

22 publications have been identified in PubMed for florid cemento-osseous dysplasia. Research spans Case Report / Case Series (55%), Review / Meta-Analysis (27%), and Clinical Trial Publication (9%).

Research Type	Count	% of Total
Patient case studies	12	55%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:58 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:83451

GARD

Genetic and Rare Diseases Info Center

GARD:10173

Questions for Your Care Team

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florid cemento-osseous dysplasia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

florid cemento-osseous dysplasia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications