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oral submucous fibrosis (OSMF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

oral submucous fibrosis

MONDO:0018166

Also known as:OSMForal cavity submucous fibrosisoral submucosal fibrosis

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Overview

Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.

Clinical Trials3 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Narrow mouth, Abnormal oral cavity morphology, Abnormality of the pharynx, and Cheilitis; and common findings: Trismus and Flexion contracture. 7 total HPO annotations.

Organ System	Phenotype Count	Example Features
Muscles	1	Flexion contracture

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Diagnosis

Biomarker and diagnostic research for oral submucous fibrosis has been reported in the published literature.

Prognosis

Phenotype severity distribution: 4 very common features, 2 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered, 1 recruiting. Interventions under study include drug therapy, other interventions, and biologic therapy. Pipeline includes 1 PHASE3, 2 NA. Research is primarily sponsored by academic and government institutions.

251 publications have been identified in PubMed for oral submucous fibrosis. Kisho has analyzed 101 by research type. Research spans Review / Meta-Analysis (39%), Basic Science / Preclinical (31%), and Diagnostic / Biomarker (11%).

Research Type	Count	% of Total
Research summaries	39

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 5:34 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:357154

GARD

Genetic and Rare Diseases Info Center

GARD:7264

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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oral submucous fibrosis

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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