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Focal facial dermal dysplasia type I (FFDD1), also known as Brauer syndrome, is a focal facial dysplasia (FFDD) characterized by congenital bitemporal cutis aplasia.
Features include: Bitemporal forceps marks, Distichiasis, Low-set ears, and Sparse lateral eyebrow.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for focal facial dermal dysplasia type I.
10 publications have been identified in PubMed for focal facial dermal dysplasia type I. Research spans Review / Meta-Analysis (33%), Case Report / Case Series (22%), and Other (11%).
Guerra NP (2026). [PMID: 41882046](https://pubmed.ncbi.nlm.nih.gov/41882046/). *Sci Rep*. [Basic Science / Preclinical]
Giamarellos-Bourboulis EJ (2026). [PMID: 41359996](https://pubmed.ncbi.nlm.nih.gov/41359996/). *JAMA*. [Clinical Trial Publication]
Prasanna S (2026). [PMID: 41717942](https://pubmed.ncbi.nlm.nih.gov/41717942/). *Indian Dermatol Online J*. [Review / Meta-Analysis]
Di Marco G (2025). [PMID: 40265342](https://pubmed.ncbi.nlm.nih.gov/40265342/). *Dermatopathology (Basel)*. [Review / Meta-Analysis]
Beyens A (2025). [PMID: 39828664](https://pubmed.ncbi.nlm.nih.gov/39828664/). *Clin Genet*. [Case Report / Case Series]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:32 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
GBD 2021 Risk Factors Collaborators (2024). [PMID: 38762324](https://pubmed.ncbi.nlm.nih.gov/38762324/). *Lancet*. [Epidemiology / Natural History]
Brauer T (2024). [PMID: 39176347](https://pubmed.ncbi.nlm.nih.gov/39176347/). *Cureus*. [Review / Meta-Analysis]
Rodenbach RA (2024). [PMID: 38341898](https://pubmed.ncbi.nlm.nih.gov/38341898/). *Patient Educ Couns*. [Other]