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Focal palmoplantar and gingival keratoderma is a very rare form of focal palmoplantar keratoderma characterized by painful circumscribed hyperkeratotic lesions on weight-bearing areas of soles, moderate focal hyperkeratosis of palmar pressure-related areas and an asymptomatic leukokeratosis confined to labial- and lingual- attached gingiva. Additional occasional features may include hyperhidrosis, follicular keratosis and extended oral mucosa involvement.
Features include: Subungual hyperkeratosis, Gingival hyperkeratosis, Focal friction-related palmoplantar hyperkeratosis, and Circumungual hyperkeratosis.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 4 | Subungual hyperkeratosis, Gingival hyperkeratosis, Focal friction-related palmoplantar hyperkeratosis |
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 6:19 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center