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Hereditary painful callosities is a nummular palmoplantar keratoderma characterized by the development of painful keratotic lesions over pressure points in hands and feet. A few families have been described. Transmission is autosomal dominant. Successful analgesia can be obtained with tretinoin.
Features include: Abnormality of the skin.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 1 | Abnormality of the skin |
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for hereditary painful callosities.
2 publications have been identified in PubMed for hereditary painful callosities. Research spans Case Report / Case Series (100%).
Moriwaki D (2025). [PMID: 40248560](https://pubmed.ncbi.nlm.nih.gov/40248560/). *Cureus*. [Case Report / Case Series]
Siriwardene M (2025). [PMID: 40510775](https://pubmed.ncbi.nlm.nih.gov/40510775/). *JAAD Case Rep*. [Case Report / Case Series]
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center