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A very rare neonatal epileptic encephalopathy disorder characterized clinically by myoclonic and clonic, or clonic seizures associated with apnea occurring several hours to 5 days after birth and responding to folinic acid.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for folinic acid-responsive seizures.
3 publications have been identified in PubMed for folinic acid-responsive seizures. Research spans Case Report / Case Series (67%) and Epidemiology / Natural History (33%).
Lee JZC (2025). [PMID: 40589945](https://pubmed.ncbi.nlm.nih.gov/40589945/). *Molecular genetics and metabolism reports*. [Case Report / Case Series]
Nabbout R (2025). [PMID: 40192341](https://pubmed.ncbi.nlm.nih.gov/40192341/). *Epilepsia*. [Epidemiology / Natural History]
Almutair M (2024). [PMID: 39236564](https://pubmed.ncbi.nlm.nih.gov/39236564/). *Molecular genetics and metabolism*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 9:14 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center