Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

Back to Frontotemporal Dementia

Frontotemporal Dementia — NIH Grants & Funding

Active and recent NIH-funded research on Frontotemporal Dementia. Data from NIH RePORTER, last 36 months.

MONDO:0017276

NIH-funded research on Frontotemporal Dementia

135

active grants

institutions

204

researchers

new in last 12 mo.

$260.1M in NIH funding over the last 36 months. Data from NIH RePORTER.

I'm looking for:

Or filter by research focus

Only show active grants

Basic Science(121)

Basic ScienceRF1Active

tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathies

Krichevsky, Anna·BRIGHAM AND WOMEN'S HOSPITAL·BOSTON, MA

$3,672,952 (FY2025)

Frontotemporal Dementia — NIH Grants & Funding

Basic Science(121)

tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathies

From Molecules To Complex Syndromes: Using Networks to Understand Heterogeneity in FTD-TDP and Aging

Upstream pathogenesis in familial and sporadic frontotemporal dementia and motor neuron disease

Role of TRIM11 in regulating TDP-43 and FUS

Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTD

Regulation and impact of shortened TDP43 isoforms in FTD and ALS

Targeting Dysregulated RNA Splicing in Neurodegenerative Diseases

iPSC-based Model to Study Frontotemporal Dementia Due to MAPT Mutation

Resolving the function of progranulin in lysosomal lipid metabolism and the etiology of Alzheimer's disease and frontotemporal dementia

The impact of progranulin species on TDP-43 proteolysis and pathobiology

Translational(11)

Frontotemporal Dementia: Genes, Images, and Emotions

3D in vitro model of genetic and sporadic FTD: accelerating novel therapeutic development

Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations

A novel approach to restore functional TDP43 for the treatment of FTD and ALS

Development of Emergent PET Tracers in Frontotemporal Lobar Degeneration

Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD

Next-generation antisense therapeutics for ALS and frontotemporal dementia

Discovering targeted modulator of microglial activity as a candidate treatment for FTD and related dementias.

Development of a brain penetrating single-chain antibody selectively targeting three repeat tau protein as a new treatment for frontotemporal dementia

Clinical(18)

Antisocial Behavior in Frontotemporal Dementia: Behavioral Phenotypes, Neural Markers, and Decision-Making Mechanisms

Emotion network dysfunction and decline in early frontotemporal dementia

Defining TBK1-associated autophagy networks in neurons

STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

Mechanisms of gain-of-repeat-toxicity and loss-of-C9ORF72-function in FTD and ALS

Characterizing autonomic impairments in Frontotemporal Dementia

Mechanisms of disruption of axon transport of autophagic vesicles and lysosomes in C9orf72 ALS

Mechanisms of Neurodegeneration in KIF5A ALS/FTD

CLINICAL/ALZHEIMERS RESEARCH PROJECT: Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimer's disease and related dementias

A mixed methods approach to understanding dementia caregiver stress when caring for a person with empathy loss

Epi / Nat. History(7)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)

Biological drivers of sex differences in frontotemporal dementia

Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease

Frontotemporal dementia in rhesus macaques

Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia

ALLFTD: ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration

Molecular pathways linking frontotemporal dementia and circadian dysfunction

Gene/Cell Therapy(10)

Genetic Contributions to Phenotypic Heterogeneity in the ALS-FTD Spectrum

Mechanism of ALS/FTD determined by multimodal single cell spatial transcriptomics

CRISPR for tauopathy

Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD

C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches

Antisense Oligonucleotides for Targeting Nonsense-mediated mRNA Decay in Frontotemporal Dementia

Developing RNA Oligonucleotides to Mitigate Abberant FUS Phase Transition in FTD/ALS

C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches

Antisense Oligonucleotides for Progranulin-deficient Frontotemporal Dementia

The Progranulin C-Terminal Domain and AAV-Progranulin Gene Therapy for Frontotemporal Dementia

Biomarker / Dx(14)

Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases

Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets

Center for Alzheimer's and Related Dementias: Detection of cryptic exons (splicing differences) in TDP-43 as biomarkers for frontotemporal dementia and Alzheimer's disease

Automated speech assessment for diagnosis of FTD spectrum disorders

Pathology-guided biofluid biomarker strategies for classification and progression of frontotemporal lobar degeneration (FTLD)

Frontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insight

A Novel Blood Test for Early Diagnosis of Frontotemporal Lobar Degeneration

Deubiquitinase USP19 in TDP-43 pathogenesis.

Development of selective amyloid-responsive fluorescent probes

Imaging Iron-Rich Pathology to Monitor and Diagnose FLTD Subtypes

Medical Device(1)

A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes

Other(10)

Precision Editing of Granulin Mutations that Cause Frontotemporal Dementia

The role of a metazoan-specific PQC system in protecting against TDP-43 proteinopathies

Mechanisms of Novel Regulators of Proteotoxicity and Quality Control Associated with ALS/FTD

Deciphering the molecular landscape of frontotemporal lobar degeneration: A network-based proteomic approach

Digital monitoring of autonomic activity to detect empathy loss in behavioral variant frontotemporal dementia

Mapping cerebellar influence in FTD: unraveling the role of the cerebellum in social cognition and clinical trajectory

Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementia

Optimizing Clinical Trial Endpoints in Frontotemporal Dementia

Cognitive and Neural Mechanisms of Antisocial Behavior in Frontotemporal Dementia

Investigating the role of traumatic injury in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD)