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Biomarker and diagnostic research for fungal keratitis has been reported in the published literature.
No approved treatments are currently available for fungal keratitis. An additional 2 compounds hold orphan drug designation.
While no drugs are FDA-approved specifically for fungal keratitis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for fungal keratitis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
2 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE3, 1 PHASE2. Research is sponsored by a mix of industry and academic institutions.
200 publications have been identified in PubMed for fungal keratitis. Kisho has analyzed 106 by research type. Research spans Review / Meta-Analysis (30%), Basic Science / Preclinical (22%), and Case Report / Case Series (14%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 32 |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 12:45 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Designated
Exclusivity End |
|---|
Designation Status |
|---|
povidone iodine | povidone iodine | IVIEW Therapeutics, Inc | 2025 | — | Designated |
Polihexanide | Polihexanide | SIFI SpA | 2022 | — | Designated |
Gene therapy approaches for fungal keratitis have been reported in the published literature.
2 trials found
30%
Laboratory research | 23 | 22% |
Patient case studies | 15 | 14% |
New treatment approaches | 13 | 12% |
Disease patterns and progression | 12 | 11% |
Clinical study results | 6 | 6% |
Testing and diagnosis research | 3 | 3% |
Other research | 2 | 2% |
Hallur V (2026). [PMID: 42069084](https://pubmed.ncbi.nlm.nih.gov/42069084/). *Indian J Med Microbiol*. [Gene Therapy / Novel Therapeutics]
Gurnani B (2026). [PMID: 36512659](https://pubmed.ncbi.nlm.nih.gov/36512659/). *Unknown Journal*. [Epidemiology / Natural History]
Arici M (2026). [PMID: 42142178](https://pubmed.ncbi.nlm.nih.gov/42142178/). *Int Ophthalmol*. [Review / Meta-Analysis]
Hsu J (2026). [PMID: 42133633](https://pubmed.ncbi.nlm.nih.gov/42133633/). *Cornea*. [Review / Meta-Analysis]
Seitz B (2026). [PMID: 41591449](https://pubmed.ncbi.nlm.nih.gov/41591449/). *Ophthalmologie*. [Review / Meta-Analysis]
Song S (2026). [PMID: 41676152](https://pubmed.ncbi.nlm.nih.gov/41676152/). *Front Immunol*. [Gene Therapy / Novel Therapeutics]
Mochizuki K (2026). [PMID: 42219348](https://pubmed.ncbi.nlm.nih.gov/42219348/). *Med Mycol J*. [Review / Meta-Analysis]
Kaur A (2026). [PMID: 41930013](https://pubmed.ncbi.nlm.nih.gov/41930013/). *Oman J Ophthalmol*. [Case Report / Case Series]
Badruddin GH (2026). [PMID: 41930031](https://pubmed.ncbi.nlm.nih.gov/41930031/). *Oman J Ophthalmol*. [Review / Meta-Analysis]
Wu S (2026). [PMID: 40738473](https://pubmed.ncbi.nlm.nih.gov/40738473/). *J Adv Res*. [Basic Science / Preclinical]