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herpes simplex virus keratitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

herpes simplex virus keratitis

MONDO:0015288

Also known as:HSV keratitisSimplexvirus caused keratitisSimplexvirus keratitis

Overview

A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (keratitis, dendritic). (Dictionary of Visual Science, 3d ed)

TreatmentsNo approved treatments · 1 in pipeline

Diagnosis

Biomarker and diagnostic research for herpes simplex virus keratitis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for herpes simplex virus keratitis. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for herpes simplex virus keratitis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for herpes simplex virus keratitis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for herpes simplex virus keratitis.

95 publications have been identified in PubMed for herpes simplex virus keratitis. Research spans Basic Science / Preclinical (39%), Case Report / Case Series (17%), and Gene Therapy / Novel Therapeutics (16%).

Research Type	Count	% of Total
Laboratory research	37	39%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:59 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:137586

Questions for Your Care Team

→What is the current development status of acyclovir, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

herpes simplex virus keratitis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

Orphanet

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report.

Fellow-eye herpes simplex virus type 1 uveitis after intravitreal bevacizumab: a case report.

Basics of Neonatal Herpes Simplex Virus.

herpes simplex virus keratitis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

Orphanet

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report.

Fellow-eye herpes simplex virus type 1 uveitis after intravitreal bevacizumab: a case report.

Basics of Neonatal Herpes Simplex Virus.