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A neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume. There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular.
Biomarker and diagnostic research for ganglioneuroblastoma has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
17 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 5 PHASE3, 3 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06296732](https://clinicaltrials.gov/study/NCT06296732) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:23 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Abdominal Neuroblastoma Laparoscopic Surgery Risk Factors Stratification |
— |
Federal Research Institute of Pediatric Hematology, Oncology and Immunology |
RECRUITING |
[NCT05192980](https://clinicaltrials.gov/study/NCT05192980) | SIOPEN BIOPORTAL, An International Registry Linked to a Virtual Biobank for Patients With Peripheral Neuroblastic Tumours | NA | Institut Curie | RECRUITING |
[NCT06172296](https://clinicaltrials.gov/study/NCT06172296) | Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma | PHASE3 | National Cancer Institute (NCI) | RECRUITING |
[NCT07375563](https://clinicaltrials.gov/study/NCT07375563) | Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and Ganglioneuroblastoma | PHASE3 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | RECRUITING |
[NCT06071897](https://clinicaltrials.gov/study/NCT06071897) | Induction Chemoimmunotherapy for Patients With High-risk Neuroblastoma | PHASE3 | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | RECRUITING |
63 publications have been identified in PubMed for ganglioneuroblastoma. Research spans Case Report / Case Series (43%), Diagnostic / Biomarker (21%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 27 | 43% |
Testing and diagnosis research | 13 | 21% |
Laboratory research | 8 | 13% |
Disease patterns and progression | 7 | 11% |
Clinical study results | 4 | 6% |
Research summaries | 3 | 5% |
New treatment approaches | 1 | 2% |
Dai X (2026). [PMID: 42158706](https://pubmed.ncbi.nlm.nih.gov/42158706/). *Transl Pediatr*. [Case Report / Case Series]
Zhang G (2026). [PMID: 41652556](https://pubmed.ncbi.nlm.nih.gov/41652556/). *BMC cancer*. [Diagnostic / Biomarker]
Tao T (2026). [PMID: 41490991](https://pubmed.ncbi.nlm.nih.gov/41490991/). *Cancer research communications*. [Diagnostic / Biomarker]
Shen C (2026). [PMID: 42099517](https://pubmed.ncbi.nlm.nih.gov/42099517/). *Front Pediatr*. [Diagnostic / Biomarker]
Yasuda K (2026). [PMID: 42256326](https://pubmed.ncbi.nlm.nih.gov/42256326/). *IJU Case Rep*. [Case Report / Case Series]
Shimizu H (2026). [PMID: 41891982](https://pubmed.ncbi.nlm.nih.gov/41891982/). *J Pediatr Hematol Oncol*. [Case Report / Case Series]
Wang X (2026). [PMID: 42138624](https://pubmed.ncbi.nlm.nih.gov/42138624/). *Int J Surg Pathol*. [Case Report / Case Series]
Fang Y (2026). [PMID: 41490645](https://pubmed.ncbi.nlm.nih.gov/41490645/). *Zhonghua bing li xue za zhi = Chinese journal of pathology*. [Diagnostic / Biomarker]
Gengler C (2026). [PMID: 40835512](https://pubmed.ncbi.nlm.nih.gov/40835512/). *Ann Pathol*. [Review / Meta-Analysis]
Conces MR (2026). [PMID: 41612478](https://pubmed.ncbi.nlm.nih.gov/41612478/). *Diagnostic pathology*. [Review / Meta-Analysis]