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genetic epilepsy with febrile seizures plus spectrum (GEFS+) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

genetic epilepsy with febrile seizures plus spectrum

MONDO:0800489

Also known as:GEFS+

Overview

A neonatal/infantile-onset self-limited familial syndrome characterized by the presence of febrile seizures in an individual with a family history of seizures/epilepsy. Febrile seizures may be typical febrile seizures or 'febrile seizures plus' (FS+) may occur, where febrile seizures continue past 6 years of age and/or are accompanied by afebrile seizures which may be generalized or focal. FS+ and GEFS+ are distinguished on the basis of family history. A number of dominantly inherited genes have been linked to both GEFS+ and FS+, with implications for specific genetic counselling, due to the variable severity of the epilepsy in different family members. Although febrile seizures are the hallmark of this familial syndrome, not all individuals in a family may have these.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for genetic epilepsy with febrile seizures plus spectrum.

106 publications have been identified in PubMed for genetic epilepsy with febrile seizures plus spectrum. Kisho has analyzed 38 by research type. Research spans Review / Meta-Analysis (34%), Basic Science / Preclinical (32%), and Epidemiology / Natural History (16%).

Research Type	Count	% of Total
Research summaries	13	34%

Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 6:07 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

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genetic epilepsy with febrile seizures plus spectrum

Overview

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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