Grayson-Wilbrandt corneal dystrophy (GWCD) is an extremely rare eye condition that affects the cornea, which is the clear outer layer of the eye. In this condition, there are variable patterns of opacification (or cloudiness) in the Bowman layer of the cornea. These changes may extend into the epithelium, the very top layer of the cornea, which plays an important role in vision clarity. Visual acuity, meaning the sharpness of vision, can be decreased in some cases while remaining normal in others. Because the patterns of opacification vary from person to person, further details about the full range of symptoms and progression are not fully known. Research is still ongoing to improve understanding of GWCD.

People with this condition may experience changes in vision, where visual clarity might be decreased in some cases. The variability in opacification patterns can contribute to differences in how the condition affects vision from one person to another. Information about additional symptoms is currently limited for this condition.

Information about causes is currently limited for this condition.