GRN-related frontotemporal lobar degeneration with Tdp43 inclusions

GRN-related frontotemporal lobar degeneration with Tdp43 inclusions is a type of frontotemporal dementia. This condition is mainly marked by changes in social behavior, language, and personality, rather than problems with memory or movement. The disease shows varied symptoms in different individuals, which means that some people may experience more challenges in social and language areas while others might have different patterns of decline. The condition involves the accumulation of Tdp43 protein inclusions in the brain, and it is linked to mutations in the GRN gene. These genetic changes disrupt normal brain function, leading to the clinical features seen in people with this form of dementia.

Common symptoms in people with this condition include difficulties with language and changes in behavior and social interactions. Instead of memory loss, challenges may appear as problems with speech, understanding language, or shifts in personality.

The main cause of this condition is a mutation in the GRN gene on chromosome 17q21.31. This genetic mutation leads to abnormal changes in brain proteins, such as Tdp43, which are implicated in the disease. The mutation is hereditary, meaning it can run in families.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.