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hallux varus-preaxial polysyndactyly syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hallux varus-preaxial polysyndactyly syndrome

MONDO:0009321

Also known as:Kleiner-Holmes syndromehallux varus and preaxial polysyndactyly

Overview

Hallux varus-preaxial polysyndactyly syndrome is a rare, genetic, congenital limb malformation disorder characterized by bilateral medial displacement of the hallux and preaxial polysyndactyly of the first toes. Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of distal phalanges. There have been no further descriptions in the literature since 1980.

GeneticsAutosomal recessive

Clinical Presentation

Features include: Preaxial hand polydactyly, Broad hallux, Syndactyly, and Hallux varus.

Organ System	Phenotype Count	Example Features
Arms and legs	1	Preaxial hand polydactyly

Explore clinical features

Diagnosis

Biomarker and diagnostic research for hallux varus-preaxial polysyndactyly syndrome has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hallux varus-preaxial polysyndactyly syndrome.

124 publications have been identified in PubMed for hallux varus-preaxial polysyndactyly syndrome. Research spans Review / Meta-Analysis (68%), Basic Science / Preclinical (15%), and Case Report / Case Series (6%).

Research Type	Count	% of Total
Research summaries	84	68%

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 5:31 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:234280

Orphanet

European rare disease database

Orphanet:2110

GARD

Genetic and Rare Diseases Info Center

GARD:3118

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hallux varus-preaxial polysyndactyly syndrome

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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