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hand-Schuller-Christian disease - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hand-Schuller-Christian disease

MONDO:0020519

Also known as:chronic multifocal Langerhans cell histiocytosisclassic multifocal Langerhans cell histiocytosishand-SChüller-Christian disease

Find Clinical TrialsTrials

Overview

A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions.

Clinical Trials14 registered · 9 recruiting

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

14 clinical trials registered, 9 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 3 PHASE3, 8 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05915208](https://clinicaltrials.gov/study/NCT05915208)

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 3:07 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:99873

GARD

Genetic and Rare Diseases Info Center

GARD:6567

Questions for Your Care Team

→Are any of the 14 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Patient case studies	8	73%
Research summaries	2	18%
Disease patterns and progression	1	9%

hand-Schuller-Christian disease

Overview

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications