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Mild microcytic anemia caused by variation in two of the four copies of the alpha hemoglobin genes, which can be in cis (e.g., large deletion of HBA1 and HBA2 genes) or in trans (e.g., HBA1 variant on one chromosome and HBA2 variant on the other chromosome).
Biomarker and diagnostic research for HBA1; HBA2-related digenic alpha thalassemia spectrum has been reported in the published literature.
No clinical trials have been registered for HBA1; HBA2-related digenic alpha thalassemia spectrum.
18 publications have been identified in PubMed for HBA1; HBA2-related digenic alpha thalassemia spectrum. Research spans Case Report / Case Series (50%), Epidemiology / Natural History (28%), and Diagnostic / Biomarker (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 9 | 50% |
Data assembled from 2 of 12 sources · Last updated Sep 20, 2026, 8:43 AM UTC
Common questions about HBA1; HBA2-related digenic alpha thalassemia spectrum
Disease patterns and progression |
5 |
28% |
Testing and diagnosis research | 2 | 11% |
Research summaries | 2 | 11% |
Mueller SM (2026). [PMID: 41511357](https://pubmed.ncbi.nlm.nih.gov/41511357/). *Cells*. [Review / Meta-Analysis]
Alanzi A (2025). [PMID: 41103898](https://pubmed.ncbi.nlm.nih.gov/41103898/). *Cureus*. [Case Report / Case Series]
Chen A (2025). [PMID: 39995439](https://pubmed.ncbi.nlm.nih.gov/39995439/). *Journal of mass spectrometry and advances in the clinical lab*. [Diagnostic / Biomarker]
Sun X (2025). [PMID: 40764933](https://pubmed.ncbi.nlm.nih.gov/40764933/). *Journal of medical case reports*. [Review / Meta-Analysis]
Idárraga GDO (2025). [PMID: 40080775](https://pubmed.ncbi.nlm.nih.gov/40080775/). *JBRA assisted reproduction*. [Epidemiology / Natural History]
Krutish A (2025). [PMID: 40458561](https://pubmed.ncbi.nlm.nih.gov/40458561/). *Frontiers in genetics*. [Case Report / Case Series]
Naamansen AB (2025). [PMID: 39651840](https://pubmed.ncbi.nlm.nih.gov/39651840/). *American journal of hematology*. [Epidemiology / Natural History]
Jiang F (2025). [PMID: 39934429](https://pubmed.ncbi.nlm.nih.gov/39934429/). *Annals of hematology*. [Case Report / Case Series]
Shook LM (2025). [PMID: 39982346](https://pubmed.ncbi.nlm.nih.gov/39982346/). *International journal of neonatal screening*. [Diagnostic / Biomarker]
Xu J (2025). [PMID: 40129608](https://pubmed.ncbi.nlm.nih.gov/40129608/). *Frontiers in genetics*. [Case Report / Case Series]