HBA1; HBA2-related digenic alpha thalassemia spectrum

HBA1; HBA2-related digenic alpha thalassemia spectrum is a condition that causes mild microcytic anemia. This condition occurs because of variations in two of the four copies of the alpha hemoglobin genes. The changes in the genes can occur in two ways: either in cis (such as a large deletion involving both the HBA1 and HBA2 genes on the same chromosome) or in trans (a variant in HBA1 on one chromosome and a variant in HBA2 on the other chromosome). This summary provides an overview based on the available definition. The nature of the genetic variations leads to the production of smaller than normal red blood cells (microcytic anemia), which is a key characteristic of this condition.

The main feature noted in this condition is mild microcytic anemia. There is limited additional information available about other symptoms or signs.

This condition is caused by variations in two of the four copies of the alpha hemoglobin genes. These genetic changes can occur in different arrangements, either in cis or in trans, which affects how the genes work together to produce normal hemoglobin.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research is currently limited for this condition.