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hearing loss, autosomal dominant 75 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hearing loss, autosomal dominant 75

MONDO:0032911

Also known as:DEAFNESS, AUTOSOMAL DOMINANT 75DFNA75

Overview

GeneticsAutosomal dominant · TRRAP (chr 7)

OnsetADULT

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Inner ear hearing loss (sensorineural hearing impairment). 2 total HPO annotations.

Organ System	Phenotype Count	Example Features
Ears	2	Abnormal cochlea morphology, Inner ear hearing loss (sensorineural hearing impairment)

Age of onset: adulthood.

Explore clinical features

Genetic Landscape

TRRAP function has not been fully characterized.

Hearing loss, autosomal dominant 75 is associated with mutations in the TRRAP gene on chromosome 7.

Diagnosis

Genetic testing for TRRAP is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hearing loss, autosomal dominant 75 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hearing loss, autosomal dominant 75.

17 publications have been identified in PubMed for hearing loss, autosomal dominant 75. Kisho has analyzed 12 by research type. Research spans Case Report / Case Series (42%), Epidemiology / Natural History (25%), and Review / Meta-Analysis (17%).

Research Type	Count	% of Total
Patient case studies	5	42%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 2:50 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:618778

GARD

Genetic and Rare Diseases Info Center

GARD:18153

Questions for Your Care Team

→Should I pursue genetic testing for TRRAP, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hearing loss, autosomal dominant 75

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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