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Hemoglobin D disease(HbD) is a hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia).
Biomarker and diagnostic research for hemoglobin D disease has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for hemoglobin D disease.
7 publications have been identified in PubMed for hemoglobin D disease. Research spans Case Report / Case Series (57%), Diagnostic / Biomarker (14%), and Review / Meta-Analysis (14%).
Sharma T (2026). [PMID: 42040700](https://pubmed.ncbi.nlm.nih.gov/42040700/). *Indian J Hematol Blood Transfus*. [Case Report / Case Series]
Bokhary M (2025). [PMID: 40777672](https://pubmed.ncbi.nlm.nih.gov/40777672/). *Cureus*. [Case Report / Case Series]
Minhas AM (2025). [PMID: 40661155](https://pubmed.ncbi.nlm.nih.gov/40661155/). *Case Rep Hematol*. [Case Report / Case Series]
Singh P (2025). [PMID: 41322744](https://pubmed.ncbi.nlm.nih.gov/41322744/). *Cureus*. [Diagnostic / Biomarker]
Shamoon M (2025). [PMID: 40451805](https://pubmed.ncbi.nlm.nih.gov/40451805/). *Hemoglobin*. [Review / Meta-Analysis]
Xu F (2025). [PMID: 40492004](https://pubmed.ncbi.nlm.nih.gov/40492004/). *Front Public Health*. [Epidemiology / Natural History]
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 8:50 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Chen Y (2024). [PMID: 39686462](https://pubmed.ncbi.nlm.nih.gov/39686462/). *Medicine (Baltimore)*. [Case Report / Case Series]