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hereditary gingival fibromatosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary gingival fibromatosis

MONDO:0016070

Also known as:autosomal dominant gingival fibromatosisautosomal dominant gingival hyperplasiahereditary gingival hyperplasia

Overview

Hereditary gingival fibromatosis (HGF) is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent (or more rarely the primary) dentition or even at birth. It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. It can be isolated, with autosomal dominant inheritance, or as part of a syndrome.

Clinical Presentation

Features include very common findings: Gingival fibromatosis and Gingival overgrowth.

Explore clinical features

Prognosis

Phenotype severity distribution: 2 very common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary gingival fibromatosis.

15 publications have been identified in PubMed for hereditary gingival fibromatosis. Research spans Case Report / Case Series (47%), Basic Science / Preclinical (27%), and Review / Meta-Analysis (13%).

Research Type	Count	% of Total
Patient case studies	7	47%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:48 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2024

GARD

Genetic and Rare Diseases Info Center

GARD:16582

Questions for Your Care Team

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hereditary gingival fibromatosis

Overview

Clinical Presentation

Explore clinical features

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

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Questions for Your Care Team

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