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fibromatosis, gingival, 5 (GGF5) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

fibromatosis, gingival, 5

MONDO:0033493

Also known as:GGF5GINGF5fibromatosis, gingival, hereditary, 5

Overview

GeneticsAutosomal dominant · REST (chr 4)

ResearchLimited published research (6 articles)

Clinical Presentation

Features include always present findings: Gingival fibromatosis; and common findings: Abnormal sternum morphology.

Explore clinical features

Genetic Landscape

REST function has not been fully characterized.

Fibromatosis, gingival, 5 is associated with mutations in the REST gene on chromosome 4.

Diagnosis

Genetic testing for REST is available. Testing is considered confirmatory for diagnosis.

Prognosis

Phenotype severity distribution: 1 always present feature, 1 common feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for fibromatosis, gingival, 5.

6 publications have been identified in PubMed for fibromatosis, gingival, 5. Research spans Case Report / Case Series (83%) and Basic Science / Preclinical (17%).

Recent Publications

Lodato V (2026). [PMID: 40605398](https://pubmed.ncbi.nlm.nih.gov/40605398/). *Clinical genetics*. [Case Report / Case Series]
Ismail H (2025). [PMID: 40425216](https://pubmed.ncbi.nlm.nih.gov/40425216/). *BMJ case reports*. [Case Report / Case Series]
Vasave S (2025). [PMID: 41146777](https://pubmed.ncbi.nlm.nih.gov/41146777/). *Cureus*. [Case Report / Case Series]
Papadopoulou E (2024). [PMID: 39727460](https://pubmed.ncbi.nlm.nih.gov/39727460/). *Dentistry journal*. [Case Report / Case Series]
Chaisrisawadisuk S (2024). [PMID: 38847516](https://pubmed.ncbi.nlm.nih.gov/38847516/). *The Journal of craniofacial surgery*. [Case Report / Case Series]

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 7:50 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:617626

GARD

Genetic and Rare Diseases Info Center

GARD:18357

Questions for Your Care Team

→Should I pursue genetic testing for REST, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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fibromatosis, gingival, 5

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team