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hereditary nonpolyposis colon cancer (HNPCC) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary nonpolyposis colon cancer

MONDO:0018630

Also known as:HNPCCHereditary nonpolyposis colorectal cancer (HNPCC)colorectal cancer, hereditary nonpolyposis

Find Clinical TrialsTrials

Overview

A cancer-predisposing condition characterized by the development of colorectal cancer not associated with colorectal polyposis, endometrial cancer, and various other cancers (such as malignant epithelial tumor of ovary, gastric, biliary tract, small bowel, and urinary tract cancer) that are frequently diagnosed at an early age.

Clinical Trials17 registered · 13 recruiting

Diagnosis

Biomarker and diagnostic research for hereditary nonpolyposis colon cancer has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

17 clinical trials registered, 13 recruiting. Interventions under study include other interventions and drug therapy. Pipeline includes 2 PHASE2, 2 PHASE1, 5 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05495776](https://clinicaltrials.gov/study/NCT05495776)

Data assembled from 4 of 12 sources · Last updated Nov 3, 2026, 2:51 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:443909

Questions for Your Care Team

→Are any of the 17 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	3	27%
Laboratory research	3	27%
Disease patterns and progression	2	18%
Other research	1	9%
Testing and diagnosis research	1	9%
Patient case studies	1	9%

hereditary nonpolyposis colon cancer

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications