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hereditary spastic paraplegia 25 (SPG25) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary spastic paraplegia 25

MONDO:0011992

Also known as:SPG25autosomal recessive spastic paraplegia 25autosomal recessive spastic paraplegia type 25

Overview

Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, complex type of hereditary spastic paraplegia characterized by adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The SPG25 phenotype has been mapped to a locus on chromosome 6q23-q24.1.

GeneticsAutosomal recessive

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Paraparesis and Herniation of intervertebral nuclei; and common findings: Spastic paraplegia, Neck pain, Sensory neuropathy, and Lower limb pain. 15 total HPO annotations.

Organ System	Phenotype Count	Example Features
Brain and nerves	3	Spastic paraplegia, Sensory neuropathy, Nerve damage affecting sensation and movement (sensorimotor neuropathy)

Diagnosis

Biomarker and diagnostic research for hereditary spastic paraplegia 25 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 very common features, 4 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary spastic paraplegia 25.

28 publications have been identified in PubMed for hereditary spastic paraplegia 25. Research spans Diagnostic / Biomarker (24%), Epidemiology / Natural History (24%), and Review / Meta-Analysis (16%).

Research Type	Count	% of Total
Testing and diagnosis research	6	24%

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 1:25 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:608220

Orphanet

European rare disease database

Orphanet:101005

GARD

Genetic and Rare Diseases Info Center

GARD:9582

Questions for Your Care Team

→Should my partner and I meet with a genetic counselor to discuss carrier status and family planning?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hereditary spastic paraplegia 25

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

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hereditary spastic paraplegia 25

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

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Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

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