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hereditary spastic paraplegia 36 (SPG36) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hereditary spastic paraplegia 36

MONDO:0013132

Also known as:SPG36autosomal dominant spastic paraplegia 36autosomal dominant spastic paraplegia type 36

Overview

Autosomal dominant spastic paraplegia type 36 (SPG36) is a complex form of hereditary spastic paraplegia, characterized by an onset in childhood or adulthood of progressive spastic paraplegia (with spastic gait, spasticity, lower limb weakness, pes cavus and urinary urgency) associated with the additional manifestation of peripheral sensorimotor neuropathy.

GeneticsAutosomal dominant

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Impaired vibration sensation in the lower limbs, Urinary urgency, Pes cavus, and Babinski sign and 9 more.

Organ System	Phenotype Count	Example Features
Brain and nerves	8	Babinski sign, Spastic gait, Lower limb spasticity

Diagnosis

Biomarker and diagnostic research for hereditary spastic paraplegia 36 has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hereditary spastic paraplegia 36.

15 publications have been identified in PubMed for hereditary spastic paraplegia 36. Research spans Epidemiology / Natural History (33%), Diagnostic / Biomarker (20%), and Review / Meta-Analysis (13%).

Research Type	Count	% of Total
Disease patterns and progression	5	33%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 11:55 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:613096

Orphanet

European rare disease database

Orphanet:320365

GARD

Genetic and Rare Diseases Info Center

GARD:17472

Questions for Your Care Team

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hereditary spastic paraplegia 36

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

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Recent Publications

hereditary spastic paraplegia 36

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications