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heterotaxy, visceral, 13, autosomal - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

heterotaxy, visceral, 13, autosomal

MONDO:0976134

Overview

GeneticsDAND5 (chr 19)

ResearchLimited published research (1 article)

Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

DAND5 encodes DAN domain BMP antagonist family member 5 (189 aa). Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development. Antagonist of BMP and TGF-beta signaling. Highest expression in Heart Atrial Appendage (6.3 TPM) and Heart Left Ventricle (5.0 TPM).

Heterotaxy, visceral, 13, autosomal is associated with mutations in the DAND5 gene on chromosome 19.

DAND5 is classified as a druggable target (Druggable Genome category) with score 0.0.

Diagnosis

Genetic testing for DAND5 is available. Testing is considered confirmatory for diagnosis.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for heterotaxy, visceral, 13, autosomal.

1 publication has been identified in PubMed for heterotaxy, visceral, 13, autosomal. Research spans Review / Meta-Analysis (100%).

Recent Publications

Reilly K (2024). [PMID: 38708840](https://pubmed.ncbi.nlm.nih.gov/38708840/). *Prenat Diagn*. [Review / Meta-Analysis]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:57 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:621079

Questions for Your Care Team

→Should I pursue genetic testing for DAND5, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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heterotaxy, visceral, 13, autosomal

Overview

Genetic Landscape

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

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Questions for Your Care Team

Questions for Your Care Team