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hidrotic ectodermal dysplasia, Halal type - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hidrotic ectodermal dysplasia, Halal type

MONDO:0015883

Also known as:Halal-Setton-Wang syndromeectodermal dysplasia with skin anomalies and intellectual disabilitytrichodysplasia-abnormal dermatoglyphics-intellectual disability syndrome

Overview

Hidrotic ectodermal dysplasia, Halal type is a form of ectodermal dysplasia syndrome characterized by trichodysplasia, with absent eyebrows and eyelashes, onychodysplasia, mild retrognathia, abnormal dermatoglyphics (excess of whorls on fingertips, radial loop on finger, hypothenar pattern), intellectual disability and normal teeth and sweating. Additional variable manifestations include high implanted or prominent ears, mild hearing loss, supernumerary nipple, cafC)-au-lait spots, keratosis pilaris, and irregular menses. To date, four individuals from 2 generations of a consanguineous family of Portuguese descent have been described in the literature. Males and females were equally affected. Hidrotic ectodermal dysplasia, Halal type is inherited in an autosomal recessive manner.

Diagnosis

Biomarker and diagnostic research for hidrotic ectodermal dysplasia, Halal type has been reported in the published literature.

Prognosis

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hidrotic ectodermal dysplasia, Halal type.

193 publications have been identified in PubMed for hidrotic ectodermal dysplasia, Halal type. Research spans Review / Meta-Analysis (59%), Basic Science / Preclinical (15%), and Epidemiology / Natural History (15%).

Research Type	Count	% of Total
Research summaries	98	59%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:53 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:1809

GARD

Genetic and Rare Diseases Info Center

GARD:280

Questions for Your Care Team

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hidrotic ectodermal dysplasia, Halal type

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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