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His bundle tachycardia is a very rare congenital genetic tachyarrhythmia characterized by incessant tachycardia and high morbidity and mortality.
Features include very common findings: Arrhythmia and Junctional ectopic tachycardia; and common findings: Heart muscle disease (cardiomyopathy). 4 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 4 | Heart muscle disease (cardiomyopathy), Arrhythmia, Junctional ectopic tachycardia |
No approved treatments are currently available for His bundle tachycardia. An additional 1 compound holds orphan drug designation.
While no drugs are FDA-approved specifically for His bundle tachycardia, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.
The following drugs have received orphan drug designation from the FDA for His bundle tachycardia. Orphan designation reflects regulatory interest and does not indicate approval for treatment.
Brand Name | Generic Name | Sponsor |
|---|
Phenotype severity distribution: 2 very common features, 1 common feature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for His bundle tachycardia.
44 publications have been identified in PubMed for His bundle tachycardia. Research spans Clinical Trial Publication (27%), Case Report / Case Series (23%), and Review / Meta-Analysis (20%).
Research Type | Count | % of Total |
|---|---|---|
Clinical study results | 12 | 27% |
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 2:11 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about His bundle tachycardia
Designated
Exclusivity End |
|---|
Designation Status |
|---|
ivabradine | ivabradine | Academic Pharmaceuticals | 2024 | — | Designated |
Gene therapy approaches for His bundle tachycardia have been reported in the published literature.
View trials for His bundle tachycardia
10 |
23% |
Research summaries | 9 | 20% |
Disease patterns and progression | 9 | 20% |
Laboratory research | 2 | 5% |
Other research | 1 | 2% |
New treatment approaches | 1 | 2% |
Balweel H (2026). [PMID: 41845224](https://pubmed.ncbi.nlm.nih.gov/41845224/). *BMC Cardiovasc Disord*. [Review / Meta-Analysis]
Lovrenčić L (2026). [PMID: 41702317](https://pubmed.ncbi.nlm.nih.gov/41702317/). *Journal of electrocardiology*. [Epidemiology / Natural History]
Singh M (2026). [PMID: 41949292](https://pubmed.ncbi.nlm.nih.gov/41949292/). *Paediatr Anaesth*. [Review / Meta-Analysis]
Al Kaabi S (2026). [PMID: 41659221](https://pubmed.ncbi.nlm.nih.gov/41659221/). *Sultan Qaboos University medical journal*. [Clinical Trial Publication]
Takamiya T (2026). [PMID: 42080738](https://pubmed.ncbi.nlm.nih.gov/42080738/). *J Cardiovasc Electrophysiol*. [Case Report / Case Series]
Chiem HD (2026). [PMID: 41513165](https://pubmed.ncbi.nlm.nih.gov/41513165/). *The Annals of thoracic surgery*. [Epidemiology / Natural History]
Ashraf M (2026). [PMID: 32809686](https://pubmed.ncbi.nlm.nih.gov/32809686/). *Unknown Journal*. [Review / Meta-Analysis]
Tria KG (2026). [PMID: 41732850](https://pubmed.ncbi.nlm.nih.gov/41732850/). *Cardiology in the young*. [Epidemiology / Natural History]
Feinstein MM (2026). [PMID: 41498260](https://pubmed.ncbi.nlm.nih.gov/41498260/). *Paediatric anaesthesia*. [Clinical Trial Publication]
Schiedat F (2026). [PMID: 41591408](https://pubmed.ncbi.nlm.nih.gov/41591408/). *Herzschrittmachertherapie & Elektrophysiologie*. [Clinical Trial Publication]