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multifocal atrial tachycardia (MAT) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

multifocal atrial tachycardia

MONDO:0017988

Also known as:MATchaotic atrial tachycardiamultifocal atrial tachycardia (disease)

Overview

Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic.

ResearchLimited published research (8 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Tachycardia, Abnormal PR interval, Irregular RR interval, and Irregular P-P interval; and common findings: Atrial flutter, Atrial fibrillation, Atrioventricular valve regurgitation, and Fetal tachycardia. 25 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	12	Tachycardia, Atrial flutter, Atrial fibrillation

Prognosis

Phenotype severity distribution: 4 always present features, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for multifocal atrial tachycardia.

12 publications have been identified in PubMed for multifocal atrial tachycardia. Kisho has analyzed 8 by research type. Research spans Clinical Trial Publication (38%), Case Report / Case Series (25%), and Epidemiology / Natural History (25%).

Recent Publications

Kong LC (2026). [PMID: 41709802](https://pubmed.ncbi.nlm.nih.gov/41709802/). *JACC Case Rep*. [Case Report / Case Series]
Custer AM (2026). [PMID: 29083603](https://pubmed.ncbi.nlm.nih.gov/29083603/). *Unknown Journal*. [Review / Meta-Analysis]
Taliercio V (2026). [PMID: 42037199](https://pubmed.ncbi.nlm.nih.gov/42037199/). *Am J Med Genet A*. [Case Report / Case Series]
Elsharkawi A (2026). [PMID: 39536147](https://pubmed.ncbi.nlm.nih.gov/39536147/). *Unknown Journal*. [Clinical Trial Publication]
Zhang A (2025). [PMID: 40098315](https://pubmed.ncbi.nlm.nih.gov/40098315/). *J Cardiovasc Electrophysiol*. [Clinical Trial Publication]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:3282

GARD

Genetic and Rare Diseases Info Center

GARD:1235

Questions for Your Care Team

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Kisho

multifocal atrial tachycardia

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Catheter Ablation of Atrial Tachycardia Originating From the Posterior Wall of the Left Atrium Following Prior Atrial Fibrillation Ablation: A Case Report.

multifocal atrial tachycardia

Overview

Clinical Presentation

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Catheter Ablation of Atrial Tachycardia Originating From the Posterior Wall of the Left Atrium Following Prior Atrial Fibrillation Ablation: A Case Report.