Holzgreve-Wagner-Rehder syndrome is a rare condition characterized by a series of congenital abnormalities. People with this condition can have features that include a pattern known as Potter sequence, heart defects, cleft palate, extra fingers or toes (polydactyly), and other skeletal defects. This means that several body parts may not develop as expected during pregnancy. The syndrome is recognized by its multiple malformations, which can affect the kidneys, heart, face, and bones. Although the exact causes are not fully detailed in the available information, the pattern of anomalies helps doctors identify and diagnose the syndrome based on its physical characteristics. The condition is also known by several other names, which reflect the range of symptoms that have been described in medical literature.

Common signs of Holzgreve-Wagner-Rehder syndrome include features of Potter sequence, congenital heart defects, cleft palate, polydactyly (extra digits), and various skeletal defects. These features may vary among individuals with the condition.

Information about causes is currently limited for this condition.