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A squamous cell carcinoma that arises from the penis and is caused by human papillomavirus infection. Morphologic variants include basaloid carcinoma and warty carcinoma.
Biomarker and diagnostic research for human papillomavirus-related penile squamous cell carcinoma has been reported in the published literature.
5 clinical trials registered, 1 recruiting. Interventions under study include biologic therapy and drug therapy. Pipeline includes 1 PHASE2, 4 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03260023](https://clinicaltrials.gov/study/NCT03260023) |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 12:40 AM UTC
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers
PHASE1 |
Transgene |
UNKNOWN |
[NCT06505551](https://clinicaltrials.gov/study/NCT06505551) | Phase 1/2 Study of Autologous SCG142 TCR T Cells in Patients With HPV16/52-positive Carcinoma | PHASE1 | SCG Cell Therapy Pte. Ltd. | NOT_YET_RECRUITING |
[NCT05686226](https://clinicaltrials.gov/study/NCT05686226) | E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers | PHASE2 | Christian Hinrichs | RECRUITING |
[NCT05973487](https://clinicaltrials.gov/study/NCT05973487) | A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors | PHASE1 | TScan Therapeutics, Inc. | ACTIVE_NOT_RECRUITING |
[NCT05639972](https://clinicaltrials.gov/study/NCT05639972) | E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers | PHASE1 | Christian Hinrichs | UNKNOWN |
16 publications have been identified in PubMed for human papillomavirus-related penile squamous cell carcinoma. Research spans Review / Meta-Analysis (38%), Epidemiology / Natural History (38%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 6 | 38% |
Disease patterns and progression | 6 | 38% |
Laboratory research | 2 | 13% |
Testing and diagnosis research | 1 | 6% |
Patient case studies | 1 | 6% |
Sali AP (2026). [PMID: 41540754](https://pubmed.ncbi.nlm.nih.gov/41540754/). *Advances in anatomic pathology*. [Review / Meta-Analysis]
Nithyanandhan K (2025). [PMID: 40752644](https://pubmed.ncbi.nlm.nih.gov/40752644/). *Indian journal of medical microbiology*. [Epidemiology / Natural History]
Shing JZ (2025). [PMID: 40412399](https://pubmed.ncbi.nlm.nih.gov/40412399/). *The Lancet. Global health*. [Epidemiology / Natural History]
Samim F (2025). [PMID: 40554707](https://pubmed.ncbi.nlm.nih.gov/40554707/). *Journal (Canadian Dental Association)*. [Case Report / Case Series]
Casanova-Martín C (2025). [PMID: 39600260](https://pubmed.ncbi.nlm.nih.gov/39600260/). *Histology and histopathology*. [Basic Science / Preclinical]
Ishiyama Y (2025). [PMID: 41301078](https://pubmed.ncbi.nlm.nih.gov/41301078/). *Cancers*. [Epidemiology / Natural History]
Pan ZK (2025). [PMID: 40678061](https://pubmed.ncbi.nlm.nih.gov/40678061/). *Frontiers in oncology*. [Diagnostic / Biomarker]
Longoni M (2025). [PMID: 39966660](https://pubmed.ncbi.nlm.nih.gov/39966660/). *Nature reviews. Urology*. [Review / Meta-Analysis]
Williams GA (2025). [PMID: 39886739](https://pubmed.ncbi.nlm.nih.gov/39886739/). *The American journal of surgical pathology*. [Epidemiology / Natural History]
Holmqvist AS (2025). [PMID: 39886926](https://pubmed.ncbi.nlm.nih.gov/39886926/). *Journal of the National Cancer Institute*. [Epidemiology / Natural History]
AI-curated news mentioning human papillomavirus-related penile squamous cell carcinoma
Updated Aug 27, 2026
Recent research on penile squamous cell carcinoma reveals candidate prognostic features through paired genomic profiling of primary tumors and lymph-node metastases. This study enhances understanding of the disease's genetic landscape, potentially guiding future therapeutic strategies.
A recent study identifies TP53/p53 status as a significant prognostic marker in penile squamous cell carcinoma. This research, which includes a cohort study and meta-analysis, enhances understanding of disease progression and potential treatment strategies.
Recent research identifies GPS1 exon 9 mutations as a rare genetic event in the pathogenesis of penile squamous cell carcinoma. This discovery could enhance understanding of the disease's molecular mechanisms.