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A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)
Biomarker and diagnostic research for squamous cell carcinoma of penis has been reported in the published literature.
15 clinical trials registered, 4 recruiting. Interventions under study include drug therapy, biologic therapy, procedural interventions, and other interventions. Pipeline includes 1 PHASE3, 8 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07217171](https://clinicaltrials.gov/study/NCT07217171) |
Data assembled from 4 of 12 sources · Last updated Nov 4, 2026, 9:37 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas |
PHASE1 |
EvolveImmune United, Inc |
RECRUITING |
[NCT05639972](https://clinicaltrials.gov/study/NCT05639972) | E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers | PHASE1 | Christian Hinrichs | RECRUITING |
[NCT05686226](https://clinicaltrials.gov/study/NCT05686226) | E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers | PHASE2 | Christian Hinrichs | RECRUITING |
[NCT06161532](https://clinicaltrials.gov/study/NCT06161532) | Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART) Such as High Grade Neuroendocrine Carcinomas, Adenocarcinoma, and Squamous Cell Bladder/Urinary Tract Cancer, Renal Medullary Carcinoma and Penile C... | PHASE2 | National Cancer Institute (NCI) | RECRUITING |
102 publications have been identified in PubMed for squamous cell carcinoma of penis. Research spans Case Report / Case Series (30%), Epidemiology / Natural History (21%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 31 | 30% |
Disease patterns and progression | 21 | 21% |
Laboratory research | 13 | 13% |
Clinical study results | 12 | 12% |
Research summaries | 11 | 11% |
Testing and diagnosis research | 9 | 9% |
Other research | 4 | 4% |
New treatment approaches | 1 | 1% |
Thiagarajan SK (2026). [PMID: 41947256](https://pubmed.ncbi.nlm.nih.gov/41947256/). *J Med Case Rep*. [Case Report / Case Series]
Adiyeri Kandiyil N (2026). [PMID: 41555526](https://pubmed.ncbi.nlm.nih.gov/41555526/). *Am J Surg Pathol*. [Basic Science / Preclinical]
Patel KN (2026). [PMID: 41638101](https://pubmed.ncbi.nlm.nih.gov/41638101/). *Eur J Surg Oncol*. [Epidemiology / Natural History]
Prasai G (2026). [PMID: 41716955](https://pubmed.ncbi.nlm.nih.gov/41716955/). *Adv Radiat Oncol*. [Clinical Trial Publication]
Paré AK (2026). [PMID: 41645694](https://pubmed.ncbi.nlm.nih.gov/41645694/). *Arch Ital Urol Androl*. [Epidemiology / Natural History]
Engelsgjerd JS (2026). [PMID: 29763105](https://pubmed.ncbi.nlm.nih.gov/29763105/). *Unknown Journal*. [Epidemiology / Natural History]
McClatchy J (2026). [PMID: 41737335](https://pubmed.ncbi.nlm.nih.gov/41737335/). *Case Rep Dermatol Med*. [Case Report / Case Series]
Collins DM (2026). [PMID: 41972286](https://pubmed.ncbi.nlm.nih.gov/41972286/). *J Investig Med High Impact Case Rep*. [Case Report / Case Series]
Paré AK (2026). [PMID: 42094088](https://pubmed.ncbi.nlm.nih.gov/42094088/). *Urol Case Rep*. [Case Report / Case Series]
Oka W (2026). [PMID: 41523918](https://pubmed.ncbi.nlm.nih.gov/41523918/). *Plast Reconstr Surg Glob Open*. [Case Report / Case Series]
AI-curated news mentioning squamous cell carcinoma of penis
Updated Oct 5, 2026
A recent case report highlights how probable Lyme disease can mimic squamous cell carcinoma, emphasizing the need for differential diagnosis in similar cases. This finding could impact clinical approaches to diagnosing skin lesions.
A recent study investigates the relationship between HPV status and histopathological prognostic factors in penile squamous cell carcinoma. The findings may provide insights into the disease's progression and potential treatment strategies.
A narrative review discusses current management and investigational therapeutic strategies for penile squamous cell carcinoma. The review highlights emerging treatment options and ongoing research efforts in this rare cancer type.