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A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)
Biomarker and diagnostic research for squamous cell carcinoma of penis has been reported in the published literature.
15 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, biologic therapy, procedural interventions, and other interventions. Pipeline includes 1 PHASE3, 8 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT07217171](https://clinicaltrials.gov/study/NCT07217171) |
Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 3:15 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas |
PHASE1 |
EvolveImmune United, Inc |
RECRUITING |
[NCT05639972](https://clinicaltrials.gov/study/NCT05639972) | E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers | PHASE1 | Christian Hinrichs | RECRUITING |
[NCT05686226](https://clinicaltrials.gov/study/NCT05686226) | E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers | PHASE2 | Christian Hinrichs | RECRUITING |
102 publications have been identified in PubMed for squamous cell carcinoma of penis. Research spans Case Report / Case Series (30%), Epidemiology / Natural History (21%), and Basic Science / Preclinical (13%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 31 | 30% |
Disease patterns and progression | 21 | 21% |
Laboratory research | 13 | 13% |
Clinical study results | 12 | 12% |
Research summaries | 11 | 11% |
Testing and diagnosis research | 9 | 9% |
Other research | 4 | 4% |
New treatment approaches | 1 | 1% |
Thiagarajan SK (2026). [PMID: 41947256](https://pubmed.ncbi.nlm.nih.gov/41947256/). *J Med Case Rep*. [Case Report / Case Series]
Adiyeri Kandiyil N (2026). [PMID: 41555526](https://pubmed.ncbi.nlm.nih.gov/41555526/). *Am J Surg Pathol*. [Basic Science / Preclinical]
Patel KN (2026). [PMID: 41638101](https://pubmed.ncbi.nlm.nih.gov/41638101/). *Eur J Surg Oncol*. [Epidemiology / Natural History]
Prasai G (2026). [PMID: 41716955](https://pubmed.ncbi.nlm.nih.gov/41716955/). *Adv Radiat Oncol*. [Clinical Trial Publication]
Paré AK (2026). [PMID: 41645694](https://pubmed.ncbi.nlm.nih.gov/41645694/). *Arch Ital Urol Androl*. [Epidemiology / Natural History]
Engelsgjerd JS (2026). [PMID: 29763105](https://pubmed.ncbi.nlm.nih.gov/29763105/). *Unknown Journal*. [Epidemiology / Natural History]
McClatchy J (2026). [PMID: 41737335](https://pubmed.ncbi.nlm.nih.gov/41737335/). *Case Rep Dermatol Med*. [Case Report / Case Series]
Collins DM (2026). [PMID: 41972286](https://pubmed.ncbi.nlm.nih.gov/41972286/). *J Investig Med High Impact Case Rep*. [Case Report / Case Series]
Paré AK (2026). [PMID: 42094088](https://pubmed.ncbi.nlm.nih.gov/42094088/). *Urol Case Rep*. [Case Report / Case Series]
Oka W (2026). [PMID: 41523918](https://pubmed.ncbi.nlm.nih.gov/41523918/). *Plast Reconstr Surg Glob Open*. [Case Report / Case Series]
AI-curated news mentioning squamous cell carcinoma of penis
Updated Sep 11, 2026
A case study highlights an unusual presentation of vesicocutaneous fistula resulting from invasive bladder squamous cell carcinoma. This finding may prompt further investigation into atypical manifestations of bladder cancer.
A rare case report details squamous cell carcinoma developing in a mature cystic teratoma of the ovary, presenting with a ruptured Sister Mary Joseph nodule. This case highlights the complexities and challenges in diagnosing rare ovarian tumors.
Recent research on penile squamous cell carcinoma reveals candidate prognostic features through paired genomic profiling of primary tumors and lymph-node metastases. This study enhances understanding of the disease's genetic landscape, potentially guiding future therapeutic strategies.