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A squamous cell carcinoma arising from the vagina. Human papillomavirus infection is associated with the development of vaginal intraepithelial neoplasia and invasive squamous cell carcinoma. Signs and symptoms include painless bleeding, postcoital bleeding, and urinary tract symptoms. Morphologically it resembles squamous cell carcinomas in other anatomic sites. Radiation therapy is the preferred treatment for most cases. The prognosis is related to the stage of the disease.
Biomarker and diagnostic research for vaginal squamous cell carcinoma has been reported in the published literature.
6 clinical trials registered, 1 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE3, 2 PHASE2, 3 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT02834013](https://clinicaltrials.gov/study/NCT02834013) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 12:09 PM UTC
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors |
PHASE2 |
National Cancer Institute (NCI) |
ACTIVE_NOT_RECRUITING |
[NCT02466971](https://clinicaltrials.gov/study/NCT02466971) | Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers | PHASE3 | National Cancer Institute (NCI) | UNKNOWN |
[NCT03074513](https://clinicaltrials.gov/study/NCT03074513) | Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors | PHASE2 | M.D. Anderson Cancer Center | ACTIVE_NOT_RECRUITING |
[NCT07217171](https://clinicaltrials.gov/study/NCT07217171) | A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas | PHASE1 | EvolveImmune United, Inc | RECRUITING |
[NCT02595879](https://clinicaltrials.gov/study/NCT02595879) | Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer | PHASE1 | National Cancer Institute (NCI) | ACTIVE_NOT_RECRUITING |
62 publications have been identified in PubMed for vaginal squamous cell carcinoma. Research spans Case Report / Case Series (39%), Review / Meta-Analysis (28%), and Epidemiology / Natural History (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 21 | 39% |
Research summaries | 15 | 28% |
Disease patterns and progression | 8 | 15% |
Laboratory research | 4 | 7% |
Clinical study results | 3 | 6% |
Testing and diagnosis research | 2 | 4% |
New treatment approaches | 1 | 2% |
Pathak P (2026). [PMID: 42024545](https://pubmed.ncbi.nlm.nih.gov/42024545/). *Radiographics*. [Review / Meta-Analysis]
Matas I (2026). [PMID: 41944777](https://pubmed.ncbi.nlm.nih.gov/41944777/). *Int J Cancer*. [Diagnostic / Biomarker]
Sapienza LG (2026). [PMID: 40972906](https://pubmed.ncbi.nlm.nih.gov/40972906/). *Int J Radiat Oncol Biol Phys*. [Review / Meta-Analysis]
Wong RW (2026). [PMID: 42023432](https://pubmed.ncbi.nlm.nih.gov/42023432/). *Histopathology*. [Review / Meta-Analysis]
Gardner K (2026). [PMID: 41875374](https://pubmed.ncbi.nlm.nih.gov/41875374/). *Int J Gynecol Pathol*. [Case Report / Case Series]
Lin S (2026). [PMID: 42005813](https://pubmed.ncbi.nlm.nih.gov/42005813/). *Gynecol Oncol Rep*. [Clinical Trial Publication]
Driák D (2026). [PMID: 41841535](https://pubmed.ncbi.nlm.nih.gov/41841535/). *Ceska Gynekol*. [Review / Meta-Analysis]
Joshi B (2026). [PMID: 41746166](https://pubmed.ncbi.nlm.nih.gov/41746166/). *Infect Immun*. [Basic Science / Preclinical]
Di Noia D (2026). [PMID: 41633428](https://pubmed.ncbi.nlm.nih.gov/41633428/). *J Gynecol Obstet Hum Reprod*. [Case Report / Case Series]
Taniwaki M (2025). [PMID: 40535470](https://pubmed.ncbi.nlm.nih.gov/40535470/). *Acta Histochem Cytochem*. [Basic Science / Preclinical]
AI-curated news mentioning vaginal squamous cell carcinoma
Updated Jul 18, 2026
A recent study published in PubMed examines the clinical characteristics and diagnostic performance of vaginal squamous cell carcinoma following hysterectomy. The findings contribute to the understanding of this rare cancer type and may inform future diagnostic approaches.