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vulvar squamous cell carcinoma - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

vulvar squamous cell carcinoma

MONDO:0024609

Also known as:epidermoid carcinoma of the vulvaepidermoid carcinoma of vulvaepidermoid cell carcinoma of the vulva

Find Clinical TrialsTrials

Overview

An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)

Clinical Trials15 registered · 3 recruiting

Diagnosis

Biomarker and diagnostic research for vulvar squamous cell carcinoma has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

15 clinical trials registered, 3 recruiting. Interventions under study include drug therapy, biologic therapy, other interventions, and procedural interventions. Pipeline includes 7 PHASE2, 5 PHASE1, 2 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05905315](https://clinicaltrials.gov/study/NCT05905315)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 4:18 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:494448

GARD

Genetic and Rare Diseases Info Center

GARD:22005

Questions for Your Care Team

→Are any of the 15 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	30	21%
Testing and diagnosis research	29	21%
Laboratory research	23	16%
Disease patterns and progression	23	16%
Patient case studies	18	13%
Clinical study results	12	9%
Other research	5	4%
New treatment approaches	1	1%

vulvar squamous cell carcinoma

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications