Human Prion Disease — Clinical Trials

MONDO:00189262 active·1 recruitingLast updated: Mar 19, 2026, 8:11 PM

Trial Landscape

Human Prion Disease has an emerging clinical trial program, driven by drug treatment.

Recruiting

Active Trials

By Approach

Drug Treatment2

By Phase

Phase 1

Phase 2

Sponsor Types

Academic/Other1Industry1

Top Sponsors

Ionis Pharmaceuticals, Inc.

Trial Locations

United States1 trial

Australia1 trial

Canada1 trial

France1 trial

Germany1 trial

Israel1 trial

Italy1 trial

Japan1 trial

Spain1 trial

Trials often recruit across multiple countries, so totals exceed the trial count.

2 Trials

Phase 1Recruiting

NCT06153966

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

Sponsor:Ionis Pharmaceuticals, Inc.

United StatesStarted: Jan 2024Est. completion: Jun 2030Updated: Mar 2026

Phase 1Not Yet RecruitingGene Therapy

NCT07444580

PrP-targeting siRNA Safety & Mechanism Study

Sponsor:Broad Institute of MIT and Harvard

Started: Apr 2026Est. completion: Aug 2029Updated: Mar 2026

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 19, 2026 at 8:11 PM