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This syndrome is characterized by the association of congenital hydrocephalus, centripetal obesity, hypogonadism, intellectual deficit and short stature.
Biomarker and diagnostic research for hydrocephalus-obesity-hypogonadism syndrome has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for hydrocephalus-obesity-hypogonadism syndrome.
202 publications have been identified in PubMed for hydrocephalus-obesity-hypogonadism syndrome. Kisho has analyzed 111 by research type. Research spans Review / Meta-Analysis (66%), Basic Science / Preclinical (14%), and Epidemiology / Natural History (9%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 73 | 66% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:51 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research |
16 |
14% |
Disease patterns and progression | 10 | 9% |
Patient case studies | 6 | 5% |
Other research | 2 | 2% |
Testing and diagnosis research | 2 | 2% |
Clinical study results | 2 | 2% |
Lee S (2026). [PMID: 41206258](https://pubmed.ncbi.nlm.nih.gov/41206258/). *Am J Geriatr Psychiatry*. [Review / Meta-Analysis]
Papazachariou A (2026). [PMID: 41128447](https://pubmed.ncbi.nlm.nih.gov/41128447/). *Curr Opin Clin Nutr Metab Care*. [Review / Meta-Analysis]
Anderson EN (2026). [PMID: 41468891](https://pubmed.ncbi.nlm.nih.gov/41468891/). *Am J Hum Genet*. [Basic Science / Preclinical]
Ferri C (2026). [PMID: 41798958](https://pubmed.ncbi.nlm.nih.gov/41798958/). *Front Immunol*. [Review / Meta-Analysis]
Amado C (2026). [PMID: 40975490](https://pubmed.ncbi.nlm.nih.gov/40975490/). *Ann Allergy Asthma Immunol*. [Review / Meta-Analysis]
Patel NM (2025). [PMID: 41101800](https://pubmed.ncbi.nlm.nih.gov/41101800/). *Facial Plast Surg Clin North Am*. [Review / Meta-Analysis]
Li C (2025). [PMID: 40736845](https://pubmed.ncbi.nlm.nih.gov/40736845/). *Adv Exp Med Biol*. [Review / Meta-Analysis]
Hartung KJ (2025). [PMID: 40736853](https://pubmed.ncbi.nlm.nih.gov/40736853/). *Adv Exp Med Biol*. [Review / Meta-Analysis]
Kröll-Hermi A (2025). [PMID: 41260215](https://pubmed.ncbi.nlm.nih.gov/41260215/). *Am J Hum Genet*. [Basic Science / Preclinical]
Mutai H (2025). [PMID: 39755840](https://pubmed.ncbi.nlm.nih.gov/39755840/). *Hum Genet*. [Basic Science / Preclinical]
AI-curated news mentioning hydrocephalus-obesity-hypogonadism syndrome
Updated Mar 16, 2026
Rare Disease Day 2026 highlights the ongoing struggles of families facing undiagnosed conditions, including hydrocephalus and Dandy-Walker syndrome. The event emphasizes the need for awareness and support for those dealing with complex health challenges.