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hypertrophic cardiomyopathy 25 (CMH25) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hypertrophic cardiomyopathy 25

MONDO:0011843

Also known as:CMH25TCAP hypertrophic cardiomyopathycardiomyopathy familial hypertrophic 25

Overview

Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the TCAP gene.

GeneticsAutosomal dominant · TCAP (chr 17)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Thickened heart muscle (hypertrophic cardiomyopathy) and Thickened left heart wall (left ventricular hypertrophy); and common findings: Wolff-Parkinson-White syndrome.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	2	Thickened heart muscle (hypertrophic cardiomyopathy), Thickened left heart wall (left ventricular hypertrophy)

Genetic Landscape

TCAP function has not been fully characterized.

Hypertrophic cardiomyopathy 25 is associated with mutations in the TCAP gene on chromosome 17.

Diagnosis

Genetic testing for TCAP is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hypertrophic cardiomyopathy 25 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 always present features, 1 common feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hypertrophic cardiomyopathy 25.

225 publications have been identified in PubMed for hypertrophic cardiomyopathy 25. Kisho has analyzed 85 by research type. Research spans Review / Meta-Analysis (26%), Epidemiology / Natural History (26%), and Clinical Trial Publication (22%).

Research Type	Count	% of Total
Research summaries	22	26%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 8:58 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:607487

Questions for Your Care Team

→Should I pursue genetic testing for TCAP, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hypertrophic cardiomyopathy 25

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

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hypertrophic cardiomyopathy 25

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

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Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

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