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hypertrophic cardiomyopathy 7 (CMH7) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

hypertrophic cardiomyopathy 7

MONDO:0013369

Also known as:CMH7TNNI3 hypertrophic cardiomyopathycardiomyopathy, familial hypertrophic 7

Overview

Any hypertrophic cardiomyopathy in which the cause of the disease is a mutation in the TNNI3 gene.

GeneticsAutosomal dominant · TNNI3 (chr 19)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Thickened heart muscle (hypertrophic cardiomyopathy); and common findings: Wolff-Parkinson-White syndrome and Apical hypertrophic cardiomyopathy. 5 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	4	Thickened heart muscle (hypertrophic cardiomyopathy), Atrial fibrillation, Apical hypertrophic cardiomyopathy

Genetic Landscape

TNNI3 function has not been fully characterized.

Hypertrophic cardiomyopathy 7 is associated with mutations in the TNNI3 gene on chromosome 19.

Diagnosis

Genetic testing for TNNI3 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for hypertrophic cardiomyopathy 7 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature, 2 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for hypertrophic cardiomyopathy 7.

279 publications have been identified in PubMed for hypertrophic cardiomyopathy 7. Research spans Epidemiology / Natural History (23%), Review / Meta-Analysis (18%), and Clinical Trial Publication (18%).

Research Type	Count	% of Total
Disease patterns and progression	65	23%

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 2:57 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:613690

Questions for Your Care Team

→Should I pursue genetic testing for TNNI3, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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hypertrophic cardiomyopathy 7

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

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Questions for Your Care Team

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hypertrophic cardiomyopathy 7

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications