Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
A primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter (LES) relaxation in response to deglutition.
Biomarker and diagnostic research for idiopathic achalasia has been reported in the published literature.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
26 clinical trials registered, 11 recruiting. Interventions under study include procedural interventions, other interventions, drug therapy, and medical devices. Pipeline includes 3 PHASE4, 1 PHASE3, 10 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05550194](https://clinicaltrials.gov/study/NCT05550194) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:07 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
VZV in the Enteric Nervous System: Pathogenesis and Consequences |
PHASE4 |
Vanderbilt University Medical Center |
RECRUITING |
[NCT04641702](https://clinicaltrials.gov/study/NCT04641702) | Comprehensive Esophageal Diagnostics Study | PHASE4 | Emory University | RECRUITING |
[NCT06189859](https://clinicaltrials.gov/study/NCT06189859) | Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy | PHASE3 | Cairo University | RECRUITING |
[NCT07399652](https://clinicaltrials.gov/study/NCT07399652) | Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures | NA | Asian Institute of Gastroenterology, India | RECRUITING |
[NCT06042127](https://clinicaltrials.gov/study/NCT06042127) | POEM-F for Achalasia International Study | NA | Chinese University of Hong Kong | RECRUITING |
64 publications have been identified in PubMed for idiopathic achalasia. Research spans Case Report / Case Series (39%), Clinical Trial Publication (30%), and Epidemiology / Natural History (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 25 | 39% |
Clinical study results | 19 | 30% |
Disease patterns and progression | 7 | 11% |
Laboratory research | 6 | 9% |
Other research | 3 | 5% |
Research summaries | 3 | 5% |
Testing and diagnosis research | 1 | 2% |
Mohamud EH (2026). [PMID: 42077565](https://pubmed.ncbi.nlm.nih.gov/42077565/). *Int Med Case Rep J*. [Case Report / Case Series]
Gajbhiye R (2026). [PMID: 41744127](https://pubmed.ncbi.nlm.nih.gov/41744127/). *Journal of minimal access surgery*. [Clinical Trial Publication]
Anand A (2026). [PMID: 41945477](https://pubmed.ncbi.nlm.nih.gov/41945477/). *J Minim Access Surg*. [Epidemiology / Natural History]
Parekh S (2026). [PMID: 41343145](https://pubmed.ncbi.nlm.nih.gov/41343145/). *Clinical journal of gastroenterology*. [Case Report / Case Series]
Gabriel SA (2026). [PMID: 41590393](https://pubmed.ncbi.nlm.nih.gov/41590393/). *Khirurgiia*. [Clinical Trial Publication]
Deo KB (2026). [PMID: 41660497](https://pubmed.ncbi.nlm.nih.gov/41660497/). *Frontiers in surgery*. [Epidemiology / Natural History]
Rai P (2026). [PMID: 41686306](https://pubmed.ncbi.nlm.nih.gov/41686306/). *Digestive diseases and sciences*. [Clinical Trial Publication]
Kotsiliti E (2026). [PMID: 41326824](https://pubmed.ncbi.nlm.nih.gov/41326824/). *Nature reviews. Gastroenterology & hepatology*. [Basic Science / Preclinical]
Vaithiyam V (2026). [PMID: 41646609](https://pubmed.ncbi.nlm.nih.gov/41646609/). *Cureus*. [Case Report / Case Series]
Marripati BK (2026). [PMID: 42064659](https://pubmed.ncbi.nlm.nih.gov/42064659/). *J Indian Assoc Pediatr Surg*. [Case Report / Case Series]
AI-curated news mentioning idiopathic achalasia
Updated May 25, 2026
A recent study identifies a frameshift variant in the FAM129C gene that contributes to achalasia via B cell responses against the GABA(A) receptor. This discovery enhances understanding of the genetic factors involved in achalasia.
Recent research sheds light on the etiology and pathogenesis of idiopathic achalasia, an inflammatory disease affecting esophageal motility. Understanding these mechanisms may lead to improved treatment strategies for patients.
A case report highlights the pathological findings of achalasia in a patient with unresectable esophageal cancer who achieved a complete response after chemotherapy. This study contributes to the understanding of the relationship between achalasia and esophageal cancer.