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A primary esophageal motor disorder characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter (LES) relaxation in response to deglutition.
Biomarker and diagnostic research for idiopathic achalasia has been reported in the published literature.
Estimated prevalence: 1-9 in 100,000 (Uncommon).
26 clinical trials registered, 10 recruiting. Interventions under study include procedural interventions, other interventions, drug therapy, and medical devices. Pipeline includes 3 PHASE4, 1 PHASE3, 10 NA. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT05550194](https://clinicaltrials.gov/study/NCT05550194) |
Data assembled from 4 of 12 sources · Last updated Nov 3, 2026, 5:02 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
VZV in the Enteric Nervous System: Pathogenesis and Consequences |
PHASE4 |
Vanderbilt University Medical Center |
RECRUITING |
[NCT04641702](https://clinicaltrials.gov/study/NCT04641702) | Comprehensive Esophageal Diagnostics Study | PHASE4 | Emory University | RECRUITING |
[NCT06189859](https://clinicaltrials.gov/study/NCT06189859) | Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy | PHASE3 | Cairo University | RECRUITING |
[NCT06042127](https://clinicaltrials.gov/study/NCT06042127) | POEM-F for Achalasia International Study | NA | Chinese University of Hong Kong | RECRUITING |
[NCT05905016](https://clinicaltrials.gov/study/NCT05905016) | Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders | — | AdventHealth | RECRUITING |
64 publications have been identified in PubMed for idiopathic achalasia. Research spans Case Report / Case Series (39%), Clinical Trial Publication (30%), and Epidemiology / Natural History (11%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 25 | 39% |
Clinical study results | 19 | 30% |
Disease patterns and progression | 7 | 11% |
Laboratory research | 6 | 9% |
Other research | 3 | 5% |
Research summaries | 3 | 5% |
Testing and diagnosis research | 1 | 2% |
Mohamud EH (2026). [PMID: 42077565](https://pubmed.ncbi.nlm.nih.gov/42077565/). *Int Med Case Rep J*. [Case Report / Case Series]
Gajbhiye R (2026). [PMID: 41744127](https://pubmed.ncbi.nlm.nih.gov/41744127/). *Journal of minimal access surgery*. [Clinical Trial Publication]
Anand A (2026). [PMID: 41945477](https://pubmed.ncbi.nlm.nih.gov/41945477/). *J Minim Access Surg*. [Epidemiology / Natural History]
Parekh S (2026). [PMID: 41343145](https://pubmed.ncbi.nlm.nih.gov/41343145/). *Clinical journal of gastroenterology*. [Case Report / Case Series]
Gabriel SA (2026). [PMID: 41590393](https://pubmed.ncbi.nlm.nih.gov/41590393/). *Khirurgiia*. [Clinical Trial Publication]
Deo KB (2026). [PMID: 41660497](https://pubmed.ncbi.nlm.nih.gov/41660497/). *Frontiers in surgery*. [Epidemiology / Natural History]
Rai P (2026). [PMID: 41686306](https://pubmed.ncbi.nlm.nih.gov/41686306/). *Digestive diseases and sciences*. [Clinical Trial Publication]
Kotsiliti E (2026). [PMID: 41326824](https://pubmed.ncbi.nlm.nih.gov/41326824/). *Nature reviews. Gastroenterology & hepatology*. [Basic Science / Preclinical]
Vaithiyam V (2026). [PMID: 41646609](https://pubmed.ncbi.nlm.nih.gov/41646609/). *Cureus*. [Case Report / Case Series]
Marripati BK (2026). [PMID: 42064659](https://pubmed.ncbi.nlm.nih.gov/42064659/). *J Indian Assoc Pediatr Surg*. [Case Report / Case Series]
AI-curated news mentioning idiopathic achalasia
Updated Oct 14, 2026
A case report highlights intractable hiccups as an initial manifestation of achalasia, providing new insights into the disease's presentation. This finding may aid in early diagnosis and management of achalasia.
A study identifies the first Asian family cluster with Riddle syndrome linked to an RNF168 mutation, presenting with pulmonary fibrosis and achalasia. This discovery adds to the understanding of the genetic basis of Riddle syndrome.
A study published in PubMed highlights the positive impact of educational pamphlets on the care of achalasia patients in Pakistan. This research suggests that education can serve as a therapeutic tool, improving patient outcomes.