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immunodeficiency due to a late component of complement deficiency - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

immunodeficiency due to a late component of complement deficiency

MONDO:0015700

Also known as:deficiency of complement of terminal pathwayimmunodeficiency due to C5 to C9 component complement deficiencyimmunodeficiency due to a C5 to C9 component complement deficiency

Overview

A genetic deficiency of any membrane attack complex (MAC, also known as terminal component complex (TCC)) component of the complement system (C5, C6, C7, C8, C9). Deficiencies of the terminal complement pathway results in a predisposition to infections, such as invasive meningococcal disease or disseminated gonococcal infection.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for immunodeficiency due to a late component of complement deficiency.

25 publications have been identified in PubMed for immunodeficiency due to a late component of complement deficiency. Research spans Basic Science / Preclinical (56%), Review / Meta-Analysis (16%), and Gene Therapy / Novel Therapeutics (12%).

Research Type	Count	% of Total
Laboratory research	14	56%

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 6:56 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:169150

GARD

Genetic and Rare Diseases Info Center

GARD:17050

Questions for Your Care Team

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immunodeficiency due to a late component of complement deficiency

Overview

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications