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immunodeficiency with defective T-cell response to interleukin 1 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

immunodeficiency with defective T-cell response to interleukin 1

MONDO:0009464

Also known as:immunodeficiency with defective T-cell response to Interleukin type 1Interleukin 1, defective T-cell response to

Overview

GeneticsAutosomal recessive, X-linked

ResearchLimited published research (5 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Recurrent otitis media, Recurrent pneumonia, and Growth delay.

Organ System	Phenotype Count	Example Features
Ears	1	Recurrent otitis media
Lungs and breathing

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for immunodeficiency with defective T-cell response to interleukin 1.

5 publications have been identified in PubMed for immunodeficiency with defective T-cell response to interleukin 1. Research spans Review / Meta-Analysis (20%), Case Report / Case Series (20%), and Clinical Trial Publication (20%).

Recent Publications

Aljohani AH (2026). [PMID: 41714512](https://pubmed.ncbi.nlm.nih.gov/41714512/). *J Clin Immunol*. [Review / Meta-Analysis]
Xiao M (2026). [PMID: 42022807](https://pubmed.ncbi.nlm.nih.gov/42022807/). *Front Cell Infect Microbiol*. [Epidemiology / Natural History]
Jean EE (2025). [PMID: 40073150](https://pubmed.ncbi.nlm.nih.gov/40073150/). *Journal of immunology (Baltimore, Md. : 1950)*. [Basic Science / Preclinical]
Ma J (2025). [PMID: 40182600](https://pubmed.ncbi.nlm.nih.gov/40182600/). *World journal of gastroenterology*. [Clinical Trial Publication]
Niehues T (2024). [PMID: 39381601](https://pubmed.ncbi.nlm.nih.gov/39381601/). *Allergologie select*. [Case Report / Case Series]

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 5:40 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:243110

Questions for Your Care Team

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immunodeficiency with defective T-cell response to interleukin 1

Overview

Clinical Presentation

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

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Questions for Your Care Team

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