IGKC encodes immunoglobulin kappa constant (107 aa). Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. Highest expression in Spleen (26,683 TPM) and Minor Salivary Gland (13,358 TPM).

Recurrent infections associated with rare immunoglobulin isotypes deficiency has limited evidence linking it to mutations in the IGKC gene on chromosome 2.

IGKC is classified as a druggable target (Druggable Genome category) with score 0.0.

Genetic testing for IGKC is available. Testing is considered research-grade for diagnosis.

Biomarker and diagnostic research for recurrent infections associated with rare immunoglobulin isotypes deficiency has been reported in the published literature.

Phenotype severity distribution: 2 always present features, 8 common features.

Estimated prevalence: Unknown (Unknown prevalence).

No clinical trials have been registered for recurrent infections associated with rare immunoglobulin isotypes deficiency.

19 publications have been identified in PubMed for recurrent infections associated with rare immunoglobulin isotypes deficiency. Research spans Review / Meta-Analysis (32%), Epidemiology / Natural History (32%), and Case Report / Case Series (16%).

Recent Publications

• Yegin Katran Z (2026). [PMID: 41841266](https://pubmed.ncbi.nlm.nih.gov/41841266/). *J Asthma*. [Epidemiology / Natural History]

• Petersen AG (2026). [PMID: 41087302](https://pubmed.ncbi.nlm.nih.gov/41087302/). *Clin Otolaryngol*. [Diagnostic / Biomarker]

• Hlongwa L (2026). [PMID: 41692833](https://pubmed.ncbi.nlm.nih.gov/41692833/). *Sci Rep*. [Basic Science / Preclinical]

• Lewandrowski C (2026). [PMID: 41451820](https://pubmed.ncbi.nlm.nih.gov/41451820/). *Curr Opin Allergy Clin Immunol*. [Review / Meta-Analysis]

• Zygadło J (2026). [PMID: 41482727](https://pubmed.ncbi.nlm.nih.gov/41482727/). *Pediatr Allergy Immunol*. [Review / Meta-Analysis]

• Ural Z (2025). [PMID: 40464874](https://pubmed.ncbi.nlm.nih.gov/40464874/). *CEN Case Rep*. [Case Report / Case Series]

• Chen X (2025). [PMID: 40948744](https://pubmed.ncbi.nlm.nih.gov/40948744/). *Front Immunol*. [Case Report / Case Series]

• Suárez-Cuartín G (2025). [PMID: 41517428](https://pubmed.ncbi.nlm.nih.gov/41517428/). *J Clin Med*. [Review / Meta-Analysis]

• Burnim M (2025). [PMID: 39441116](https://pubmed.ncbi.nlm.nih.gov/39441116/). *Am J Respir Crit Care Med*. [Epidemiology / Natural History]

• Dogru D (2025). [PMID: 40313941](https://pubmed.ncbi.nlm.nih.gov/40313941/). *Front Immunol*. [Epidemiology / Natural History]