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inherited ichthyosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

inherited ichthyosis

MONDO:0015947

Also known as:congenital ichthyosis of skingenetic ichthyosishereditary ichthyosis (disease)

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Overview

Mendelian disorders of cornification affecting all or most of integument characterized by hyperkeratosis and/or scaling, caused by an inherited modification of the individual's genome.

TreatmentsNo approved treatments · 6 in pipeline

Clinical Trials7 registered · 3 recruiting

Diagnosis

Biomarker and diagnostic research for inherited ichthyosis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for inherited ichthyosis. An additional 6 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for inherited ichthyosis, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for inherited ichthyosis. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

7 clinical trials registered, 3 recruiting. Interventions under study include other interventions, drug therapy, and medical devices. Pipeline includes 2 PHASE2, 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT03417856](https://clinicaltrials.gov/study/NCT03417856)

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 6:39 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:183435

GARD

Genetic and Rare Diseases Info Center

GARD:20261

Questions for Your Care Team

→Are any of the 7 active clinical trials a good fit for my situation?
→With 6 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	80	38%
Research summaries	41	20%
Laboratory research	37	18%
Disease patterns and progression	18	9%
New treatment approaches	15	7%
Other research	8	4%
Testing and diagnosis research	8	4%
Clinical study results	3	1%

inherited ichthyosis

Overview

Diagnosis

Treatment

Orphan Drug Designations

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

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